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Chiral Polypeptide Thermogels Induce Controlled Inflammatory Response as Potential Immunoadjuvants. | LitMetric

Chiral Polypeptide Thermogels Induce Controlled Inflammatory Response as Potential Immunoadjuvants.

ACS Appl Mater Interfaces

Key Laboratory of Polymer Ecomaterials , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street , Changchun 130022 , P. R. China.

Published: March 2019

AI Article Synopsis

  • The study investigates how different chiral thermogels made from a specific polypeptide can influence the inflammatory response when implanted in vivo.
  • Two types of thermogels (EGLA and EGDA) were found to produce a stronger and more controllable inflammatory reaction compared to a racemic version (EGRA).
  • The presence of d-alanine in the thermogels allowed researchers to modulate the levels of inflammatory markers such as TNF-α and IL-6, suggesting these materials could be effective adjuvants for immunotherapy.

Article Abstract

The in vivo implanted biomaterials are known to induce inflammatory response and recruit immune cells, which could be used as robust adjuvants for immunotherapy. However, the degree of inflammatory response induced by the implanted biomaterials is hard to control. In this work, we reported the application of three kinds of thermogels from the polypeptide methoxy poly(ethylene glycol)-polyalanine (mPEG-PAla) with various chiralities to regulate the levels of inflammatory responses in vivo. The mPEG-PLAla (EGLA) and mPEG-PDAal (EGDA) thermogels exhibited comparable storage modulus ( G') and loss modulus ( G″), both of which were about two times higher than the values of the racemic mPEG-PAla (EGRA) thermogel. The component d-alanine in the polypeptide thermogels led to controlled tissue inflammation after subcutaneous injection, and the content of d-alanine could adjust the level of inflammation. The expression of tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in subcutaneous tissue around the injected thermogel EGDA were 3.62, 1.52, and 4.55 times the levels of those after EGRA thermogel injection and 4.52, 7.38, and 7.96 times the levels of those after EGLA injection, respectively. The results indicated that the chiral polypeptide thermogels could induce a controllable inflammatory response in vivo and exhibit great potential as an efficient adjuvant for immunotherapy.

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Source
http://dx.doi.org/10.1021/acsami.9b01872DOI Listing

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