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Improving communication to increase uptake of high-risk breast cancer prevention appointments: Building a better letter.
PEC Innov
December 2024
Indiana University School of Medicine, Indianapolis, IN, USA.
Objective: Mailed letters to women identified as being at high-risk for developing breast cancer were not having the desired effect for encouraging appointments with prevention-focused providers at a large Midwest healthcare system. A partnership with communication scholars sought to revise the letter to increase awareness, intentions, and appointments.
Methods: Guided by the Extended Parallel Process Model, survey responses were collected from letter recipients over the course of two years, both pre and post letter revision.
Application of Strontium Chloride Hexahydrate to Synthesize Strontium-Substituted Carbonate Apatite as a pH-Sensitive, Biologically Safe, and Highly Efficient siRNA Nanocarrier.
ACS Appl Bio Mater
January 2025
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
Naked siRNAs are sensitive to enzymatic degradation, phagocytic entrapment, quick renal excretion, membrane impermeability, endosomal escape, and off-target effects. Designing a safe and efficient nanocarrier for siRNA delivery to the target site without toxicity remains a significant hurdle in gene therapy. CA is a unique derivative of hydroxyapatite and a highly pH-sensitive nanocarrier with strong particle aggregation and a high polydispersity index.
View Article and Find Full Text PDFNetwork and stoichiometry analysis revealed a fast magnesium and calcium deficiency of mulched .
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The Research Centre for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing, China.
The imbalanced fertilization and the consequential deterioration on the rhizosphere microbial community (RMC) were two potential reasons for the quick yielding degradation of (Lei-bamboo), a high-value shoot-oriented bamboo. However, most research only focused on nitrogen, phosphorus, and potassium; the studies on the dynamics of other nutrients, such as calcium and magnesium; and their driving mechanisms, lags far behind. Thus, Lei-bamboo fields of different mulching and recovery ages were selected to investigate the dynamics of calcium and magnesium in both soil and bamboo tissue, and to explore their relationship to RMC composition and network patterns.
View Article and Find Full Text PDFSafety and efficacy of sertraline in depression among adults undergoing dialysis: a systematic review and meta-analysis.
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Department of Internal Medicine, Nepal Medical College, Gokarneshwar, Nepal.
Background: Depression is prevalent among patients with end-stage renal disease (ESRD) undergoing dialysis, with significant implications for their quality of life and treatment compliance. Traditional treatments for depression, including various therapies and pharmacological interventions, have limitations due to their adverse effects. Sertraline, a selective serotonin re-uptake inhibitor (SSRI), offers a promising alternative, but its efficacy and safety in this population require thorough evaluation.
View Article and Find Full Text PDFCirculating GLAST EVs are increased in amyotrophic lateral sclerosis.
Front Mol Biosci
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Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, Novara, Italy.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, hallmarked by the gradual deterioration of motor neurons, culminating in muscle weakness and fatal paralysis. The exact etiology of ALS remains elusive, and there is a critical need for reliable biomarkers to aid in diagnosis and monitoring of disease progression. Extracellular vesicles (EVs) have emerged as promising candidates for biomarker discovery in neurodegenerative diseases such as ALS, giving access to pathologically relevant tissues otherwise typically challenging or invasive to sample.
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