Dihydroartemisinin-piperaquine, which was registered in 2017 in Senegal, is not currently used as the first-line treatment against uncomplicated malaria. A total of 6.6% to 17.1% of isolates collected in Dakar in 2013 to 2015 showed -reduced susceptibility to piperaquine. Neither the exonuclease E415G mutation nor the copy number variation of the gene (), associated with piperaquine resistance in Cambodia, was detected in Senegalese parasites.
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| http://dx.doi.org/10.1128/AAC.02445-18 | DOI Listing |
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