Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury.

Tau protein (encoded by the gene microtubule-associated protein tau, ) is essential for the assembly and stability of microtubule and the functional maintenance of the nervous system. Tau is highly abundant in neurons and is detectable in astrocytes and oligodendrocytes. However, whether tau is present in Schwann cells, the unique glial cells in the peripheral nervous system, is unclear. Here, we investigated the presence of tau and its coding mRNA, , in cultured Schwann cells and find that tau is present in these cells. Gene silencing of promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. application of siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistent with this, -knockout mice showed elevated proliferation and reduced migration of Schwann cells. Rats injected with siRNA and -knockout mice also exhibited impaired myelin and lipid debris clearance. The expression and distribution of the cytoskeleton proteins α-tubulin and F-actin were also disrupted in these animals. These findings demonstrate the existence and biological effects of tau in Schwann cells, and expand our understanding of the function of tau in the nervous system.