The aim of the present work was to develop a computational model of how children acquire inflectional morphology for marking person and number; one of the central challenges in language development. First, in order to establish which putative learning phenomena are sufficiently robust to constitute a target for modelling, we ran large-scale elicited production studies with native learners of Finnish (N = 77; 35-63 months) and Polish (N = 81; 35-59 months), using a novel method that, unlike previous studies, allows for elicitation of all six person/number forms in the paradigm (first, second and third person; singular and plural). We then proceeded to build and test a connectionist model of the acquisition of person/number marking which not only acquires near adult-like mastery of the system (including generalisation to unseen items), but also yields all of the key phenomena observed in the elicited-production studies; specifically, effects of token frequency and phonological neighbourhood density of the target form, and a pattern whereby errors generally reflect the replacement of low frequency targets by higher-frequency forms of the same verb, or forms with the same person/number as the target, but with a suffix from an inappropriate conjugation class. The findings demonstrate that acquisition of even highly complex systems of inflectional morphology can be accounted for by a theoretical model that assumes rote storage and phonological analogy, as opposed to formal symbolic rules.
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http://dx.doi.org/10.1016/j.cogpsych.2019.02.001 | DOI Listing |
Cells
December 2024
Neuroscience Institute, Section of Padova, National Research Council (CNR), 35131 Padova, Italy.
Astrocytes from different brain regions respond with Ca elevations to the catecholamine norepinephrine (NE). However, whether this noradrenergic-mediated signaling is present in astrocytes from the ventral tegmental area (VTA), a dopaminergic circuit receiving noradrenergic inputs, has not yet been investigated. To fill in this gap, we applied a pharmacological approach along with two-photon microscopy and an AAV strategy to express a genetically encoded calcium indicator in VTA astrocytes.
View Article and Find Full Text PDFBMC Public Health
January 2025
Health & Nutrition Cluster, Institute of Development Studies, University of Sussex, Brighton, UK.
Background: Global re-emergence of the zoonotic viral disease, Mpox (Monkeypox) has drawn global attention, leading to its declaration as a Public Health Emergency of International Concern (PHEIC) by World Health Organisation (WHO) in July 2022. Nigeria is a spotlight identified for the viral disease outbreak, with attention drawn on its transmission to non-endemic nations. With the country's healthcare challenges, care seeking practices particularly amongst low-income urban informal settlement populations are diverse - presenting challenges to both case identification and management during an outbreak.
View Article and Find Full Text PDFJ Control Release
January 2025
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address:
Most subunit antigens often induce suboptimal vaccination efficacy, possibly due to their low immunogenicity and limited ability to migrate to lymph nodes (LNs). Although the emergence of nanovaccine has significantly addressed these challenges, most formulations still require specific biological or chemical modifications to the carrier or antigen for efficient antigen loading. In this study, we report a Pickering emulsion-based nanovaccine that directly utilized antigens and adjuvants as stabilizers, effectively amplifying immune responses without additional physicochemical alterations.
View Article and Find Full Text PDFNeurosci Res
January 2025
Center for Brain Behavior and Metabolism, University of Lübeck, Germany. Electronic address:
Pronouns create cohesive links in discourse by referring to previously mentioned elements. Here, we focus on pronominalization during speech production in three experiments employing ERP and fMRI methodologies. Participants were asked to produce two short sentences describing a man or woman using an object.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
Université de Reims Champagne Ardenne, INRAE, RIBP USC 1488, 51100 Reims, France.
Stilbenes are specialized metabolites that are particularly abundant in species. Although the biosynthetic pathways of stilbenes have been well-characterized, the role of specific peroxidases in stilbene oligomerization remains to be investigated. In this study, we used grapevine cell cultures to characterize the functional role of peroxidase 4 (VvPRX4) in the production of resveratrol oligomers after elicitation with methyl jasmonate (MeJA).
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