Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0038-1657077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets.
Res Pract Thromb Haemost
August 2024
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Background: Our prior genome-wide association study of thrombin-induced platelet aggregation identified a G protein-coupled receptor kinase 5 (GRK5) noncoding variant (rs10886430-G) that is strongly associated with increased platelet reactivity to thrombin. This variant predisposes to increased risk of stroke, pulmonary embolism, and venous thromboembolism.
Objectives: To determine role of platelet specific GRK5 in platelet responses to agonists and injury.
The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo.
J Ginseng Res
September 2023
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Background: The anti-platelet activity of the saponin fraction of Korean Red Ginseng has been widely studied. The saponin fraction consists of the panaxadiol fraction (PDF) and panaxatriol fraction (PTF); however, their anti-platelet activity is yet to be compared. Our study aimed to investigate the potency of anti-platelet activity of PDF and PTF and to elucidate how well they retain their anti-platelet activity via different administration routes.
View Article and Find Full Text PDFDaboxin P, a phospholipase A of Indian Daboia russelii venom, modulates thrombin-mediated platelet aggregation.
J Biochem Mol Toxicol
November 2023
Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam, India.
Daboxin P, reported earlier from the venom of Daboia russellii, disturbs the blood coagulation cascade by targeting factor X and factor Xa. The present study exhibits that Daboxin P also inhibits platelet aggregation induced by various agonists. The thrombin-induced platelet aggregation was inhibited maximum whereas inhibition of collagen-induced platelet aggregation was found to be 50% and no inhibition of adenosine diphosphate (ADP) and arachidonic acid-induced aggregation was observed.
View Article and Find Full Text PDFAntiplatelet Effect of Daphnetin Is Regulated by cPLA-Mediated Thromboxane A Generation in Mice.
Int J Mol Sci
March 2023
College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Coumarin derivatives have been recognized for their antithrombotic, anti-inflammatory, and antioxidant properties, and daphnetin is one of the natural coumarin derivatives isolated from Nakai. Although the pharmacological value of daphnetin is well documented in diverse biological activities, its antithrombotic effect has not been studied to date. Here, we characterized the role and underlying mechanism of daphnetin in the regulation of platelet activation using murine platelets.
View Article and Find Full Text PDFPimpinellin Inhibits Collagen-induced Platelet Aggregation and Activation Through Inhibiting Granule Secretion and PI3K/Akt Pathway.
Front Pharmacol
July 2021
School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
Pimpinellin is a coumarin-like compound extracted from the root of . Its effects on platelet function has not been investigated. This study found that pimpinellin pretreatment effectively inhibited collagen-induced platelet aggregation, but did not alter ADP- and thrombin-induced aggregation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!