A P(V)-N activation method based on nucleoside phosphoropiperidate/DCI system has been developed for improved synthesis of diverse UDP-furanoses. The reaction conditions including temperature, amount of activator, and reaction time were optimized to alleviate the degradation of UDP-furanoses to cyclic phosphates. In addition, an efficient and facile phosphoramidite route was employed for the preparation of furanosyl-1-phosphates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412210 | PMC |
| http://dx.doi.org/10.3390/molecules24040655 | DOI Listing |
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