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Antifungal Activity against of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives. | LitMetric

Antifungal Activity against of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives.

Molecules

Laboratorio de Micología, Facultad de Química y Biología, Universidad de Santiago de Chile, Avenida Libertador Bernardo O'Higgins 3363, Santiago 518000, Chile.

Published: February 2019

AI Article Synopsis

Article Abstract

In this work the enzyme laccase from was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen , while the -methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions. Finally, the results suggested that these compounds produced damage in the fungal cell wall.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412631PMC
http://dx.doi.org/10.3390/molecules24040706DOI Listing

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