Unexpected events provide us with opportunities for learning about what to expect from the world around us. Using a saccadic-planning paradigm, we investigated whether and how infants and adults represent the statistics of a changing environment (i.e. build an internal model of the environment). Participants observed differently colored bees that appeared at an unexpected location every few trials. The color cues indicated whether the subsequent bees would appear at this new location (i.e. update trials) or at the same location as previously (i.e. no-update trials). Infants learned the predictive value of the color cues and updated their internal models when necessary. Unlike infants, adults had a tendency to update their models each time they observed a change in the structure. We argue that infants are open to learning from current evidence due to being less influenced by their prior knowledge. This is an advantageous learning strategy to form accurate representations in dynamic environments, which is fundamental for successful adaptation.
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http://dx.doi.org/10.1016/j.cognition.2019.02.004 | DOI Listing |
Viruses
December 2024
The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Hepatitis B virus (HBV) can cause chronic infections, significantly increasing the risk of death from cirrhosis and hepatocellular carcinoma (HCC). A key player in chronic HBV infection is covalently closed circular DNA (cccDNA), a stable episomal form of viral DNA that acts as a persistent reservoir in infected hepatocytes and drives continuous viral replication. Despite the development of several animal models, few adequately replicate cccDNA formation and maintenance, limiting our understanding of its dynamics and the evaluation of potential therapeutic interventions targeting cccDNA.
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November 2024
Department of Infectious Diseases, Molecular Virology, Section Virus-Host Interactions, Heidelberg University, 69120 Heidelberg, Germany.
The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild-type (WT) isolates was enabled by the expression of SEC14L2 and by inhibitors targeting deleterious host factors. Here, we aimed to optimize cell culture models to allow infection with HCV from patient sera.
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December 2024
School of Mechanical and Electrical Engineering, Shandong Jianzhu University, Jinan 250101, China.
Accurately predicting tool wear during the machining process not only saves machining time and improves efficiency but also ensures the production of good-quality parts and automation. This paper proposes a combined variational mode decomposition (VMD) and back propagation (BP) neural network model (VMD-BP), which maps spindle power to tool wear. The model is trained using both historical and real-time data.
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December 2024
CERN, Esplanade des Particules 1, 1217 Meyrin, Switzerland.
Device simulation plays a crucial role in complementing experimental device characterisation by enabling deeper understanding of internal physical processes. However, for simulations to be trusted, experimental validation is essential to confirm the accuracy of the conclusions drawn. In the framework of semiconductor detector characterisation, one powerful tool for such validation is the Two Photon Absorption-Transient Current Technique (TPA-TCT), which allows for highly precise, three-dimensional spatially-resolved characterisation of semiconductor detectors.
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December 2024
Psychology Department, Middle Tennessee State University, Murfreesboro, TN 37132, USA.
Consumer-grade EEG devices, such as the InteraXon Muse 2 headband, present a promising opportunity to enhance the accessibility and inclusivity of neuroscience research. However, their effectiveness in capturing language-related ERP components, such as the N400, remains underexplored. This study thus aimed to investigate the feasibility of using the Muse 2 to measure the N400 effect in a semantic relatedness judgment task.
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