AI Article Synopsis
- Recent reports indicate that DS-1-like-G1P[8] rotavirus has emerged in Asia, sparking interest in its detection in America.
- Between 2013 and 2017, researchers screened 4226 fecal samples for rotavirus, finding that G1P[8] strains accounted for 3.7% of positives, with DS-1-like-G1P[8] strains found only in 2013.
- Whole genome sequencing revealed that Brazilian strains cluster with Asian counterparts, suggesting these strains may have originated from Asia, and it emphasizes the need for effective surveillance systems to assess the efficacy of rotavirus vaccines against these emerging strains.
Article Abstract
Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. G1P[8] represented 3.7% (30/800) of all rotavirus-positive samples. DS-1-like-G1P[8] comprised 1.6% (13/800) detected exclusively in 2013, and Wa-like-G1P[8] comprised 2.1% (17/800) detected from 2013 to 2015. Whole genome sequencing confirmed the DS-1-like backbone I2-R2-C2-M2-A2-N2-T2-E2-H2. All genome segments of the Brazilian DS-1-like-G1P[8] strains clustered with those of Asian strains, and apart from African DS-1-like-G1P[8] strains. In addition, Brazilian DS-1-like-G1P[8] reassortants distantly clustered with DS-1-like backbone strains simultaneously circulating in the country, suggesting that the Brazilian DS-1-like-G1P[8] strains are likely imported from Asia. Two distinct NSP4 E2 genotype lineages were also identified, indicating the existence of a co-circulating pool of different DS-1-like G1P[8] strains. Surveillance systems must be developed to examine if RVA vaccines are still effective for the prevention against unusual DS-1-like-G1P[8] strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379365 | PMC |
| http://dx.doi.org/10.1038/s41598-019-38703-7 | DOI Listing |
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