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Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice.
Andrology
November 2024
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Background: Inhibition of sperm maturation in the epididymis is a promising post-testicular strategy for short-acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice. However, it is unknown if inhibition of ROS1 suppresses male fertility reversibly.
View Article and Find Full Text PDFIntegration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development.
Biol Sex Differ
October 2024
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Article Synopsis
- The 46,XX testicular disorder/difference of sex development (DSD) is a rare condition where individuals typically have female chromosomes (46,XX) but display male characteristics, often due to the translocation of a Y chromosome segment to the X chromosome.
- Researchers conducted extensive genetic analysis on blood samples from individuals with 46,XX DSD and controls to explore the genetic variations and their effects on phenotype.
- The study revealed distinct categories of translocated Y chromosome segments and identified transcriptional changes linked to phenotypic traits like height and testicular size, enhancing the understanding of the genetic factors involved in 46,XX DSD.
Rapid detection of mouse spermatogenic defects by testicular cellular composition analysis via enhanced deep learning model.
Andrology
October 2024
State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Article Synopsis
- Histological analysis of testicular sections is essential for infertility research but often requires extensive training, prompting the need for faster methods.
- A new deep learning model was developed to analyze mouse testicular sections stained with H&E, resulting in improved accuracy and reduced analysis time while identifying spermatogenic defects in mutant mice.
- The SCSD-Net model enables rapid assessment of reproductive defects in just 2.5-3 hours, revealing significant interactions between Sertoli and DAZ family proteins that impact testis size and meiotic function.
Changes in Testosterone Levels Following Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia: Systematic Review and Meta-Analysis.
World J Mens Health
September 2024
Global Andrology Forum, Moreland Hills, OH, USA.
Article Synopsis
- Surgical sperm retrieval (SSR) is performed to extract sperm from men with azoospermia and may result in reduced testosterone levels and other hormonal changes post-operation.* -
- A systematic review analyzed 17 studies involving 1,685 azoospermic men, revealing a significant decrease in testosterone after SSR, but no major changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), or testicular volume.* -
- The study highlights the importance of considering potential sexual dysfunction and the psychosocial impacts of SSR in postoperative care and preoperative discussions.*
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