Cryptococcus species are an encapsulated fungal pathogen that cause cryptococcal meningitis. There are limited therapeutic options for this infection. The management includes the use of different antifungals such as amphotericin B, flucytosine, or fluconazole, either alone or in combination. However, numerous therapeutic failures, as well as the limited effectiveness of such therapeutics, have been described. Diphenyl diselenide is a chemically synthesised molecule with was found to have antimicrobial activity. In this study, we evaluated the antifungal activities of fluconazole, amphotericin B and flucytosine, in combination with diphenyl diselenide against 30 clinical isolates of Cryptococcus spp. using CLSI M27-A3 method and the checkerboard microdilution technique. Our results show that the combination of flucytosine and diphenyl diselenide displayed 100% of synergism. However, when we analysed (PhSe) plus AMB or FLZ we observed around 70% of indifference. Our results suggest that the combination of diphenyl diselenide with other antifungal agents deserves attention as a new option for the development of alternative therapies for cryptococcosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/myc.12905 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chemistry to cognition: Therapeutic potential of (m-CF-PhSe) targeting rats' striatum dopamine proteins in amphetamine dependence.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (LaftamBio Pampa), Universidade Federal do Pampa, Itaqui, RS, Brazil. Electronic address:
Amphetamine (AMPH) abuse represents a major global public health issue, highlighting the urgent need for effective therapeutic interventions to manage addiction caused by this psychostimulant. This study aimed to assess the potential of m-trifluoromethyl-diphenyldiselenide [(m-CF-PhSe)] in preventing the addictive effects induced by AMPH through targeting dopamine metabolism proteins. (m-CF-PhSe) is of interest due to its demonstrated efficacy in mitigating opioid abuse, establishing it as a promising candidate for addiction treatment research.
View Article and Find Full Text PDFDiethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide.
BMC Neurosci
December 2024
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced neurotoxicity in male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts and treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) and DEN-only (200 mg/kg; single dose i.
View Article and Find Full Text PDFDiphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats.
Front Pharmacol
December 2024
Department of Pharmacology, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Introduction: Diphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions. However, it has not been clarified whether DPDS alleviates type 1 diabetic kidney disease (DKD) is related to the inhibition of extracellular matrix (ECM) production and the regulation of intestinal flora disorder.
Methods: The present study investigated the effects of DPDS on ECM generation in the kidney and intestinal microflora composition in feces.
Glucopyranosylamine-derived Dinuclear Mo(VI) Complex: An Efficient Catalyst for the Oxidation of Thiols into Uronium Aryl/Alkyl Sulfonates.
Chem Asian J
December 2024
Birla Institute of Technology and Science - Pilani Campus: Birla Institute of Technology & Science Pilani, Chemistry, Vidya Vihar, 333031, Pilani, INDIA.
Article Synopsis
- A dinuclear molybdenum complex combined with urea hydrogen peroxide has been developed as an effective catalyst for converting thiols into uronium sulfonate salts with high yields (89-98%) in ethanol at room temperature.
- The reaction produced hydrogen gas, a pioneering finding in similar oxidation processes, and detailed product characterization was conducted using techniques like FTIR, NMR, and single crystal X-ray diffraction.
- Mechanistic studies revealed intermediate products including disulfides and sulfinic acids, while two specific reactions illustrated the conversion of uronium p-chlorobenzene sulfonate to sulfonic acid and diphenyl diselenide to selenonate salt.
Photo-induced carboxylation of C(sp)-S bonds in aryl thiols and derivatives with CO.
Nat Commun
November 2024
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P. R. China.
Aryl thiols have proven to be a useful class of electron donors and hydrogen atom sources in photochemical processes. However, the direct activation and functionalization of C(sp)-S bonds in aryl thiols remains elusive in the field of photochemistry. Herein, a photochemical carboxylation of C(sp)-S bonds in aryl thiols with CO is reported, providing a synthetic route to important aryl carboxylic acids.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!