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| http://dx.doi.org/10.5114/amsad.2018.81010 | DOI Listing |
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Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects.
Biofabrication
January 2025
Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin, DO2 YN77, IRELAND.
Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic bone defects. Furthermore, the use of long-term high-dose antibiotics in standard treatment increases the risks of antibiotic resistance. Herein, an antibiotic-free, collagen silver-doped hydroxyapatite (coll-AgHA) scaffold reinforced with a 3D printed polycaprolactone (PCL) framework was developed with enhanced mechanical properties to be used in the repair of load-bearing defects with antimicrobial properties as a preventative measure against osteomyelitis.
View Article and Find Full Text PDFReal-World 12-Month Outcomes with Sirolimus-Coated Balloon Angioplasty for Complex Femoropopliteal Disease.
J Clin Med
January 2025
Department of Vascular and Endovascular Surgery, Rhein Main Vascular Center, Asklepios Clinics Langen, Paulinen Wiesbaden, 63225 Langen, Germany.
: Sirolimus-coated balloons (SCBs) have emerged as a promising alternative to paclitaxel-coated devices for the treatment of femoropopliteal lesions. However, real-world data on SCB performance in also complex peripheral arterial disease remains unknown. We sought to evaluate the safety and 12-month clinical outcomes of the Selution SLR™ balloon angioplasty in a challenging real-world patient cohort.
View Article and Find Full Text PDFNon-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.
Circ Res
January 2025
Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, PA. (R.A.C., C.C.C., R.W., A.C., C.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J. Brown, C.S.H.).
Background: Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells.
View Article and Find Full Text PDFFinding the balance: Advancing strategies for managing severely calcified coronary lesions.
Cardiovasc Revasc Med
January 2025
Department of Pharmacology, Federal University of the São Francisco Valley, Petrolina, PE, Brazil. Electronic address:
This letter to the editor provides a critical and constructive analysis of the article "Intravascular Lithotripsy Compared with Rotational Atherectomy for Calcified Coronary Lesions: A Meta-analysis of Outcomes", highlighting key methodological limitations and the exclusion of relevant contemporary studies. It emphasizes the clinical importance of addressing severely calcified coronary lesions, a significant challenge in interventional cardiology, and advocates for future research to prioritize randomized clinical trials, subgroup analyses, and cost-effectiveness evaluations to improve the applicability of findings across healthcare settings. By promoting dialogue within the scientific community and encouraging the integration of evolving data, the letter aims to refine clinical strategies and align them with evidence-based public health approaches, particularly in resource-limited environments.
View Article and Find Full Text PDFThe Role of Coronary Computed Tomography Angiography in the Diagnosis, Risk Stratification, and Management of Patients with Diabetes and Chest Pain.
Rev Cardiovasc Med
December 2024
Department of Cardiology, Heart Center, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Coronary artery disease (CAD) affects over 200 million individuals globally, accounting for approximately 9 million deaths annually. Patients living with diabetes mellitus exhibit an up to fourfold increased risk of developing CAD compared to individuals without diabetes. Furthermore, CAD is responsible for 40 to 80 percent of the observed mortality rates among patients with type 2 diabetes.
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