Bile cast nephropathy is an often overlooked condition of acute renal injury in the setting of high serum bilirubin. While the exact pathophysiology remains unknown, possible mechanisms of renal injury are tubular obstruction from bile casts, direct toxicity from bile acids, and decreased renal perfusion due to hemodynamic changes. We present a patient with hyperbilirubinemia as a result of common bile duct obstruction due to pancreatic adenocarcinoma who developed anuric acute renal injury. Urine analysis showed bile casts that were highly suggestive for bile cast nephropathy. The patient underwent hemodialysis and bile drainage with full restoration of renal function.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358578 | PMC |
| http://dx.doi.org/10.14309/crj.2018.88 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Cholemic nephropathy is an overlooked cause of acute kidney injury (AKI) in patients with advanced cirrhosis and high bilirubin plasma levels (usually above 20mg/dl), due to bilirubin and bile acid deposition in the kidneys. Those deposits have been hypothesized to cause tubular injury. It has no standardized diagnostic criteria or therapeutic strategies.
View Article and Find Full Text PDFIntraductal Polypoid Neoplasm in the Intrahepatic Large Bile Ducts of Small Duct-type Intrahepatic Cholangiocarcinoma May Result From Cancerization of Ducts.
Am J Surg Pathol
January 2025
Division of Pathology.
Article Synopsis
- A study of 121 cases of small duct-type intrahepatic cholangiocarcinoma (small duct-iCCA) identified intraductal polypoid neoplasms in 8 cases (6.6%), which showed growth patterns adjacent to mass-forming tumors.
- These polypoid neoplasms were found to have histological and immunohistochemical similarities to the primary tumors, indicating a shared biliary subtype and reflecting the cancerization of ductal tissues.
- A comparison with intraductal papillary neoplasm of the bile duct (IPNB) revealed differences, as IPNBs often presented non-invasive characteristics, suggesting that intraductal polypoid neoplasms should
Acute hepatitis A with haemophagocytic lymphohistiocytosis: G-6PD deficiency-induced haemolytic anaemia and bile cast nephropathy.
BMJ Case Rep
September 2024
Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.
Article Synopsis
- Hepatitis A virus (HAV) usually causes mild illness but can lead to severe complications like acute liver failure, which is fatal in rare cases; in 2016, it resulted in about 7,134 deaths.
- Fulminant liver failure occurs in less than 1% of acute hepatitis A cases, but unusual associations with other severe conditions like haemophagocytic lymphohistiocytosis (HLH) have been noted.
- The case presented discusses a man in his 30s with G6PD deficiency, whose acute HAV infection led to severe symptoms, including hyperacute liver failure, HLH, and renal failure.
Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct.
World J Gastrointest Oncol
May 2024
Second Department of Gastroenterology, Digestive Disease Hospital of Heilongjiang Provincial Hospital, and Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary Diseases, Harbin 150001, Heilongjiang Province, China.
Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a premalignant biliary-type epithelial neoplasm with intraductal papillary or villous growth. Currently reported local palliative therapeutic modalities, including endoscopic nasobiliary drainage, stenting and biliary curettage, endoscopic biliary polypectomy, percutaneous biliary drainage, laser ablation, argon plasma coagulation, photodynamic therapy, and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and disadvantages. We have applied percutaneous transhepatic cholangioscopy (PTCS)-assisted biliary polypectomy (PTCS-BP) technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since 2010.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!