AI Article Synopsis
- - The study explored how two specific SNPs in the interleukin-18 gene (rs187238 and rs1946518) and one SNP in another gene (rs3212227) relate to the age at which type 1 diabetes (DM1) begins.
- - A total of 1,101 DM1 patients from various regions in Brazil participated, and their genetic profiles were analyzed using a TaqMan assay based on their ancestry.
- - Findings suggest that the SNP in the second gene might influence the age of DM1 onset due to its effect on gene expression.
Article Abstract
The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 ( ) gene (rs187238, g.-137G > C; rs1946518, g.-607C > A) and one SNP of the gene (rs3212227 g.*159A > C, 3'UTR) with the age of onset for type 1 (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our results show that an SNP in gene could be associated with DM1 age onset, taking into account that this studied variation affects gene expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375717 | PMC |
| http://dx.doi.org/10.1055/s-0039-1677749 | DOI Listing |
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