An iboga alkaloid chemotaxonomic marker from endemic with antitubercular activity.

Coronaridine () was isolated from the CHCl root extract of The structure of was established from 1D- and 2D-NMR and HR-ESIMS experiments, and by comparison with reported spectroscopic data. To date, this is the first report of compound from introduced as new species from Philippines in 2005 on the basis of morphological characters. Coronaridine, an iboga-type indole alkaloid, has been isolated from over 50 species and can thus be inferred as a chemotaxonomic marker of the genus. has a distinct arrangement of leaves not known in the genus, but is variable in other genera. Its isolation from endemic establishes its position in the genus and supports the claim that coronaridine is a chemical marker of the genus Interestingly, coronaridine exhibited relatively weak activity against HRv (MIC 82.64 μg/mL) (Rifampicin MIC 0.05 μg/mL).