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Occurrence of coccidioidomycosis in a tertiary hospital in the Brazilian semi-arid region: diagnostic challenges.
Braz J Microbiol
September 2024
Department of Pathology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Coccidioidomycosis is a systemic fungal infection that primarily affects the lungs in mammals. It is endemic to certain areas of the Americas. In Brazil, the disease occurs exclusively in the Northeast of the country, and the only etiological agent described is Coccidioides posadasii, typically found in the soil of arid regions with low rainfall.
View Article and Find Full Text PDFFibrotic Contracture of the Infraspinatus Muscle with or without Contracture of the Teres Minor Muscle: A Retrospective Study in Eight Dogs.
Animals (Basel)
September 2024
Surgery & Obstetrics Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, Greece.
(1) Background: Fibrotic contracture of the canine infraspinatus muscle (FCIM) is considered an uncommon musculotendinous condition mainly affecting hunting dogs. After an acute onset of a painful non-weight-bearing lameness over a period of one to four weeks, a characteristic circumducted gait is developed in the affected thoracic limb. (2) Methods: Eight client-owned dogs of varying breeds, both sexes, aged 4-9 years old, and weighing 14-26 kg participated in the study.
View Article and Find Full Text PDFExacerbation of Osteoarthritic Joint Pain by Lyme Disease.
Cureus
April 2024
Internal Medicine/Medical Education, Arnot Ogden Medical Center/Lake Erie College of Osteopathic Medicine, Elmira, USA.
Lyme disease progresses through three distinct clinical phases: early localized, early disseminated, and late disseminated. Lyme arthritis is characterized by attacks of joint swelling lasting for weeks to months, potentially causing permanent joint damage in late disseminated disease. Our case focuses on a 63-year-old, obese, type 2 diabetic, wheelchair-bound, Caucasian male with severe bilateral knee pain.
View Article and Find Full Text PDFThe contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.
Front Neurosci
April 2024
Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, China.
Periaqueductal gray (PAG), an integration center for neuronal signals, is located in the midbrain and regulates multiple physiological and pathological behaviors, including pain, defensive and aggressive behaviors, anxiety and depression, cardiovascular response, respiration, and sleep-wake behaviors. Due to the different neuroanatomical connections and functional characteristics of the four functional columns of PAG, different subregions of PAG synergistically regulate various instinctual behaviors. In the current review, we summarized the role and possible neurobiological mechanism of different subregions of PAG in the regulation of pain, defensive and aggressive behaviors, anxiety, and depression from the perspective of the up-down neuronal circuits of PAG.
View Article and Find Full Text PDFEpidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil.
Nat Commun
April 2024
The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Article Synopsis
- Coccidioidomycosis, a fungal disease prioritized by the WHO, is frequently underreported in Central and South America, despite being endemic in the U.S. and Mexico.
- A study in Brazil's Piauí and Maranhão states discovered 292 cases and 42 outbreaks from 1978-2021, predominantly affecting male armadillo hunters, with common symptoms including cough and fever.
- The analysis indicates that lower rainfall increases disease incidence, and unique genetic strains of the fungus in Brazil suggest potential differences in how the disease behaves compared to other regions.
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