AI Article Synopsis
- The study focused on characterizing the anti-inflammatory drug eremantholide C (EREC) by examining its polymorphic and physicochemical properties to understand its biopharmaceutical classification.
- EREC was obtained from a natural source and crystallized in two solvents, with various analyses performed to assess its melting points, purity, and structural properties.
- The results indicated that EREC does not exhibit polymorphism, meaning its crystallization process does not affect its solubility or how well it can be absorbed in the body when taken orally.*
Article Abstract
Objectives: To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification.
Methods: Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction, optical microscopy and scanning electron microscopy analysis. In addition, EREC samples crystallized after intrinsic dissolution study were submitted to DSC and X-ray powder diffraction analysis.
Key Findings: EREC 1 showed fusion at 234.7-241.6 °C, while EREC 2 showed fusion at 238.6-243.7 °C. No polymorphic transitions were observed during the intrinsic dissolution experiment. A single sharp endothermic peak was obtained for the EREC samples. X-ray diffraction showed no crystallographic differences between the EREC samples. EREC 1 and EREC 2 showed birefringence under polarized light and indefinite morphology; however, the shape of the crystals was common to the two samples.
Conclusions: Eremantholide C does not present classical or morphological polymorphism; therefore, there is no influence of crystalline transitions in the solubility and consequently in its biopharmaceutics classification and oral absorption process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/jphp.13080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A qPCR assay for specific detection of pv. .
Plant Dis
September 2024
Clemson University - EREC, Plant and Environmental Sciences, 64 Research Road, Blackville, South Carolina, United States, 29817;
Pseudomonas cannabina pv. alisalensis is a gram-negative bacterium that causes bacterial leaf blight in Brassica crops, an important disease that could bring severe damage to the host plants. The aim of this study was to develop a tool that can reliably and accurately quantify P.
View Article and Find Full Text PDFRapid survey for assessing effective cataract surgical coverage (eCSC) and effective refractive error coverage (eREC)-Novel indicators of universal eye health.
Indian J Ophthalmol
September 2024
Community Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.
Purpose: As per the recent World Health Organization estimates, approximately 2.2 billion people have near and distance vision impairment (VI) globally, and out of this almost 50% is avoidable.
Methods: The Rapid Assessment of Avoidable Visual Impairment survey was a cross-sectional study conducted in September 2021, using cluster random sampling in 42 clusters with a cluster size of 140, giving a total of 6000 participants.
The exploratory dataset of isotopic composition of different water sources across Kazakhstan.
Data Brief
June 2024
School of Mining and Geosciences, Nazarbayev University, 53 Kabanbay Batyr Ave, Astana, 010000, Kazakhstan.
This work presents the dataset of stable water isotopes of oxygen and hydrogen measured in water samples from different sources (precipitation, surface water, groundwater, tap water) across Kazakhstan from 2017 to 2018 and from 2020 to 2023. The dataset includes results on isotopic composition of 399 water samples, namely precipitation: event-based ( = 108), cumulative monthly ( = 22); surface water: lakes, reservoirs, brooks, rivers, channels ( = 175), groundwater: shallow and artesian groundwater, spring ( = 85), tapwater ( = 9). For each sample name of the source, location, latitude, longitude and date of sampling, measurement uncertainty (one standard deviation) are available.
View Article and Find Full Text PDFCharacterization of class 1 integrons in metallo-β-lactamase-producing Acinetobacter baumannii isolates from hospital environment.
BMC Res Notes
December 2023
Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, 3149779453, Iran.
Background And Objective: The emergence and widespread dissemination of antibiotic resistance in A. baumannii, has become a globally challenge. The increasing hospital outbreaks by multi-drug resistant (MDR) A.
View Article and Find Full Text PDFRapid Assessment of Avoidable Visual Impairment in Two Coastal Districts of Eastern India for Determining Effective Coverage: A Cross-Sectional Study.
J Ophthalmic Vis Res
April 2023
Community Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Purpose: To measure the prevalence and causes of visual impairment (VI) among the 40+ age population in two coastal districts of India and to determine the levels of effective cataract surgical coverage (eCSC) and effective refractive error coverage (eREC) in the study population.
Methods: A cross-sectional study was done on 4200 people chosen using cluster sampling in two coastal districts of Odisha, an eastern state in India. A team consisting of trained optometrists and social workers conducted the ocular examination which included unaided, pinhole, and aided visual acuity assessments followed by examination of the anterior segment and lens.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!