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Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ("fibrositis syndrome"). | LitMetric

Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ("fibrositis syndrome").

Pain

Clinical Investigation Unit and Section of Neurochemistry, The Clarke Institute of Psychiatry, Toronto, Ont. M5T 1R8 Canada.

Published: June 1978

AI Article Synopsis

  • Plasma-free tryptophan levels are lower in patients with more severe pain symptoms related to fibrositis syndrome.
  • This study involved 8 patients diagnosed with various forms of non-articular rheumatism.
  • Findings align with previous research showing a link between decreased serotonin metabolism in the brain and heightened pain sensitivity.

Article Abstract

Plasma-free tryptophan is inversely related to the severity of subjective pain in 8 patients who fulfilled criteria for a variety of non-articular rheumatism, the "fibrositis syndrome". The observation is consistent with animal and human studies suggesting a relationship between reduced brain serotonin metabolism and pain reactivity.

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Source
http://dx.doi.org/10.1016/0304-3959(78)90025-8DOI Listing

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