AI Article Synopsis
- Advances in nanometrology focus on developing effective sample pre-treatment methods for isolating nanomaterials from complex matrixes, specifically using a novel ultrasonication technique to extract silver nanoparticles from moisturizing creams.
- This method involves a specific ultrasonication process and is paired with modern inductively coupled plasma mass spectrometry (ICP-MS), which allows for detailed analysis of nanoparticle concentration and size distribution.
- Results showed a low relative standard deviation, with high recovery rates in spike tests and established limits for quantifying Ag NPs, leading to analysis of both prescribed and regular creams for silver content and nanoparticle characterization.
Article Abstract
Advances on nanometrology require reliable sample pre-treatment methods for extracting/isolating nanomaterials from complex samples. The current development deals with a discontinuous ultrasonication (60% amplitude, 15 cycles of ultrasound treatment for 59 s plus relaxing stage for 59 s, 20 mL of methanol) method for a fast and quantitative extraction of silver nanoparticles (Ag NPs) from moisturizing creams. Possibilities offered by modern inductively coupled plasma mass spectrometry (ICP-MS) which allow 'single particle' assessment (sp-ICP-MS) have been used for Ag NPs assessment (Ag NPs concentration and Ag size distribution). The relative standard deviation (RSD) of the over-all procedure (Ag NPs concentration in eleven extracts from a same cream) was found to be 5%; whereas, the analytical recovery for spiking experiments with Ag NPs of 20, 40, and 60 nm was found to be within the 90-109% range. The limit of quantification in Ag NPs concentration was established at 8.25 × 10 Ag NPs g; whereas, the limit of detection in size was found to be within the 5-13 nm (several equations were used for calculation). Finally, moisturizing creams prescribed for atopic dermatitis and also regular moisturizing creams were analyzed for total Ag, and for Ag NPs characterization (Ag NPs concentration and Ag NPs size distribution) by sp-ICP-MS. Electronic microscopy was also used for comparative (qualitative) purposes.
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| http://dx.doi.org/10.1016/j.talanta.2019.01.068 | DOI Listing |
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