AI Article Synopsis
- Poly-L-lactic acid (PLLA) is a biodegradable synthetic polyester that breaks down into lactic acid, making it safe for medical use.
- PLLA scaffolds and nanofibers are utilized in regenerative medicine and drug delivery due to their biocompatibility, high surface area, and strength.
- The chapter discusses the methods for creating and validating 3D PLLA nanofibrous scaffolds and explores future applications in tissue engineering.
Article Abstract
Poly-L-lactic acid (PLLA) is a biodegradable synthetic polyester synthesized by polymerization or polycondensation. PLLA hydrolytically degrades into lactic acid, a biocompatible metabolic by-product, making it suitable for clinical applications. PLLA scaffolds or nanofibers have been used in various regenerative medicine and drug delivery applications. These scaffolds impart biocompatible properties of high surface area, hydrophobicity, native extracellular properties, and mechanical strength for an organ system. Moreover, PLLA nanofibers hold great promise as drug delivery systems, where fabrication parameters and drug-PLA compatibility greatly affect the drug release kinetics. In this chapter, we present the protocols to fabricate, electrospinning, and validation of 3D PLLA nanofibrous scaffolds for tissue engineering application and offer perspectives on their future use.
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| http://dx.doi.org/10.1007/7651_2019_213 | DOI Listing |
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