Since the publication of this paper, the authors have noticed that the article contains an error in Figure 3e (TSN, 50 nM). As a result of the misfiling of the data, the incorrect image was inadvertently inserted in Figure 3e during figure preparation. The corrected image is shown in this correction.
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http://dx.doi.org/10.1038/s41388-019-0738-1 | DOI Listing |
J Agric Food Chem
December 2022
School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan 450001, People's Republic of China.
To discover novel natural-product-based insecticide candidates, herein, a variety of osthole-derived -benzoylthioureas were synthesized and assessed for their insecticidal activities against three insect pests. An insecticidal assay showed that most of the target osthole-derived -benzoylthioureas displayed a more potent and broad-spectrum insecticidal effect than the parent osthole after the introduction of -benzoylthioureas on the C-3' position of osthole. Compound displayed the most potent growth inhibitory (GI) effect on Walker, with a final corrected mortality rate of 82.
View Article and Find Full Text PDFJ Agric Food Chem
July 2022
School of Pharmaceutical Sciences, Zhengzhou University, No. 100, Science Avenue, Zhengzhou, 450001 Henan Province, P. R. China.
Natural products are an abundant and environmentally friendly source for controlling plant pathogens and insect pests. Toward the development of new natural product-based pesticides, here, a series of osthole-based isoxazoline derivatives were prepared by [3 + 2] annulation and evaluated for their insecticidal activities and toxicities. The structures of all osthole-based isoxazoline derivatives were characterized by various spectral analyses, and derivative was further confirmed by X-ray crystallography.
View Article and Find Full Text PDFJ Agric Food Chem
December 2021
School of Pharmaceutical Sciences, Zhengzhou University, No. 100, Science Avenue, Zhengzhou, 450001 Henan Province, P. R. China.
To improve the insecticidal activity of (+)-nootkatone, a series of 42 (+)-nootkatone thioethers containing 1,3,4-oxadiazole/thiadiazole moieties were prepared to evaluate their insecticidal activities against Walker, Sulzer, and Linnaeus. Insecticidal evaluation revealed that most of the title derivatives exhibited more potent insecticidal activities than the precursor (+)-nootkatone after the introduction of 1,3,4-oxadiazole/thiadiazole on (+)-nootkatone. Among all of the (+)-nootkatone derivatives, compound (1 mg/mL) exhibited the best growth inhibitory (GI) activity against with a final corrected mortality rate (CMR) of 71.
View Article and Find Full Text PDFOncogene
June 2019
Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Since the publication of this paper, the authors have noticed that the article contains an error in Figure 3e (TSN, 50 nM). As a result of the misfiling of the data, the incorrect image was inadvertently inserted in Figure 3e during figure preparation. The corrected image is shown in this correction.
View Article and Find Full Text PDFJ Agric Food Chem
September 2009
Laboratory of Pharmaceutical Design and Synthesis, College of Life Sciences, Northwest A&F University, Yangling 712100, Shannxi Province, People's Republic of China.
By using podophyllotoxin as a phytoinsecticidal lead compound, 15 novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin were semisynthesized and preliminarily tested for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo for the first time. Among all of the tested compounds, especially two compounds, 4m and 4o, containing a pyridinyl group, for which final corrected mortality rates against M. separata at 1 mg/mL were 62.
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