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The economic burden of atopic dermatitis in Romania: a broad perspective.
Front Public Health
January 2025
Dermatology Department, Colentina Clinical Hospital, Bucharest, Romania.
Introduction: Atopic dermatitis (AD), a common dermatological condition, is often associated with significant economic and social burdens. Despite extensive studies globally, there is a gap in understanding the impact of this condition in Romania. This study evaluated the economic burden of AD in Romania, considering both direct and indirect costs.
View Article and Find Full Text PDFPyrrocidines A and B demonstrate synergistic inhibition of growth.
Front Microbiol
January 2025
Toxicology and Mycotoxin Research Unit, United States National Poultry Research Center, Agricultural Research Service, United States Department of Agriculture, Athens, GA, United States.
-a mycotoxigenic fungus and food safety threat-coinhabits maize kernels with . This protective endophyte produces secondary metabolites of interest, pyrrocidines A and B, which inhibit the growth of and specifically block fumonisin biosynthesis. Previous transcriptomic analyses found (FVEG_00314), a gene adjacent to the fumonisin biosynthetic gene cluster, to be induced over 4,000-fold in response to pyrrocidine challenge.
View Article and Find Full Text PDFLeveraging Quality Improvement Tools to Improve Administration of First-line Surgical Antibiotic Prophylaxis in Patients Labeled as Penicillin Allergic.
Pediatr Qual Saf
January 2025
Division of Pediatric Surgery, Dayton Children's Hospital, Dayton, Ohio.
Introduction: A reported penicillin allergy reduces the likelihood that the patient will receive first-line surgical antibiotic prophylaxis (SAP), which can increase the risk of developing a surgical site infection (SSI). This project aimed to increase the use of first-line SAP agents in orthopedic and pediatric surgery patients with a reported penicillin allergy.
Methods: The Institute for Healthcare Improvement quality improvement methodology was followed.
Single-cell sequencing of human Langerhans cells identifies altered gene expression profiles in patients with atopic dermatitis.
Immunohorizons
January 2025
Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Atopic dermatitis (AD) is characterized by dysregulated T cell immunity and skin microbiome dysbiosis with predominance of Staphylococcus aureus, which is associated with exacerbating AD skin inflammation. Specific glycosylation patterns of S. aureus cell wall structures amplify skin inflammation through interaction with Langerhans cells (LCs).
View Article and Find Full Text PDFMurine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens.
Front Immunol
January 2025
Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, United States.
Rationale: Approximately 32 million people in the United States suffer from food allergies. Some food groups, such as legumes - peanuts, tree nuts, fish, and shellfish, have a high risk of cross-reactivity. However, the murine model of multiple food group cross-reactivity is limited.
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