We report a catalytic asymmetric Nazarov cyclization of simple, acylic, alkyl-substituted divinyl ketones using our recently disclosed strong and confined imidodiphosphorimidate Brønsted acids. The corresponding monocyclic cyclopentenones are formed in good yields and excellent regio-, diastereo-, and enantioselectivities. Further, the chemical utility of the obtained enantiopure cyclopentenones is demonstrated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541325 | PMC |
| http://dx.doi.org/10.1021/jacs.8b13899 | DOI Listing |
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