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Incorporation of the Living Heart Model into the 4D XCAT Phantom for Cardiac Imaging Research. | LitMetric

Incorporation of the Living Heart Model into the 4D XCAT Phantom for Cardiac Imaging Research.

IEEE Trans Radiat Plasma Med Sci

Carl E. Ravin Advanced Imaging Laboratories, the Department of Electrical and Computer Engineering, the Department of Radiology, the Department of Biomedical Engineering, the Medical Physics Graduate Program, and the Department of Physics, Duke University, Durham, NC, 27705 USA.

Published: January 2019

AI Article Synopsis

Article Abstract

The 4D extended cardiac-torso (XCAT) phantom has provided a valuable tool to study the effects of anatomy and motion on medical images, especially cardiac motion. One limitation of the XCAT was that it did not have a physiological basis which to realistically simulate variations in cardiac function. In this work, we incorporate into the XCAT anatomy the four-chamber FE Living Heart Model (LHM) developed by the Living Heart Project (LHP). The LHM represents the state of the art in cardiac FE simulation because of its ability to accurately replicate the biomechanical motion of the entire heart and its variations. We create a new series of 4D phantoms capable of simulating patients with varying body sizes and shapes; cardiac positions, orientations, and dynamics. While extendable to other imaging modalities and technologies, our goal is to use the FE-enhanced XCAT models to investigate the optimal use of computed tomography (CT) for the evaluation of coronary artery disease (CAD). With the ability to simulate realistic, predictive, patient quality 4D imaging data, the enhanced XCAT models will enable optimization studies to identify the most promising systems or system parameters for further clinical validation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370029PMC
http://dx.doi.org/10.1109/TRPMS.2018.2823060DOI Listing

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