Chief medical residents from the 3 affiliate residency training programs at VA Boston Healthcare System developed a mission statement for the educational experience of all medical trainees rotating through VA medical centers.
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Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.
Proc Natl Acad Sci U S A
February 2025
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock-in mice with PINK1 knock-out (KO) mice and report that loss of PINK1 does not impact endogenous LRRK2-mediated Rab phosphorylation nor do we see significant effect of mutant LRRK2 on PINK1-mediated Rab and Ub phosphorylation.
View Article and Find Full Text PDFThe relationships between photochemical reflectance index (PRI) and photosynthetic status in radish species differing in salinity tolerance.
J Plant Res
January 2025
Graduate School of Life Sciences, Tohoku University, Aoba, Sendai, 980-8578, Japan.
Since photosynthesis is highly sensitive to salinity stress, remote sensing of photosynthetic status is useful for detecting salinity stress during the selection and breeding of salinity-tolerant plants. To do so, photochemical reflectance index (PRI) is a potential measure to detect conversion of the xanthophyll cycle in photosystem II. Raphanus sativus var.
View Article and Find Full Text PDFAirspace closures due to reentering space objects.
Sci Rep
January 2025
Department of Political Science, University of British Columbia, Vancouver, BC, Canada.
Uncontrolled reentries of space objects create a collision risk with aircraft in flight. While the probability of a strike is low, the consequences could be catastrophic. Moreover, the risk is rising due to increases in both reentries and flights.
View Article and Find Full Text PDFNovel bilayered zirconia systems using recycled 3Y-TZP for dental applications.
Dent Mater
January 2025
Department of Prosthodontics and Periodontology, University of São Paulo - Bauru School of Dentistry, Bauru, SP, Brazil.
Objective: To synthesize bilayer zirconia systems based on commercial or recycled 3Y-TZP obtained from non-milled remnants and to compare their optical and mechanical properties before and after aging.
Methods: Bilayer zirconia samples were fabricated using either recycled 3Y-TZP (3Y-R/4Y and 3Y-R/5Y) or commercial powders (3Y/4Y and 3Y/5Y). Microstructure and phase composition were analyzed using ScanningElectronMicroscopy (SEM) and X-Ray Diffraction (XRD).
"Fly to New World": Meeting report of the 16th Japanese Drosophila research conference (JDRC16).
Dev Growth Differ
January 2025
Laboratory for Histogenetic Dynamics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
The 16th Japanese Drosophila Research Conference (JDRC16) was held at the Sendai International Center from September 17 to 19 2024. It had been 2 years since the last JDRC15 held in Nagoya. The conference brought together 231 researchers, including 22 researchers from overseas, creating a vibrant and diverse platform for scientific exchange.
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