AI Article Synopsis
- The study evaluated the long-term outcomes of children with potential celiac disease (CD) over 10 years.
- Among 553 children with genetic predisposition for CD, only 4.7% were diagnosed with potential CD, and all were symptom-free and maintained a gluten-containing diet.
- After a decade, only 13% of those with potential CD progressed to overt CD, suggesting that the risk of this progression is low for children on a regular diet.
Article Abstract
Background: The long-term outcome of potential celiac disease (CD) is still a debated issue. We aimed to evaluate the progression of potential CD versus overt CD after 10-years of follow-up in a cohort of children genetically predisposed to CD.
Methods: The CELIPREV study is prospectively following from birth 553 children with CD-predisposing HLA genes. Children with a diagnosis of potential CD continued to receive a normal diet and repeated the serological screening for CD every year. An intestinal biopsy was taken in presence of persistent positive serology.
Results: Overall, 26 (4.7%) children received a diagnosis of potential CD (50% females, median age 24 months). All children were symptom-free. Twenty-three children continued a gluten-containing diet; at 10 years from the first biopsy, three children developed overt CD (13%), 19 (83%) became antibodies negative at 1 year from the first biopsy and remained negative up to 10 years of follow-up and one subject (4%) had fluctuating antibody course with transiently negative values and persistently negative biopsy.
Conclusions: In children genetically predisposed to CD with a diagnosis of potential CD the risk of progression to overt CD while on a gluten-containing diet is very low in the long-term.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406363 | PMC |
| http://dx.doi.org/10.3390/jcm8020186 | DOI Listing |
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