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Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments.
Microorganisms
October 2024
Nanobios Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Article Synopsis
- Ursolic acid (UA) and oleanolic acid (OA) are natural compounds with anti-mycobacterial properties but have poor solubility, limiting their use in treatment.
- Researchers developed solid lipid microparticles (SLMs) to effectively deliver UA and OA, demonstrating their ability to inhibit both drug-sensitive and multidrug-resistant tuberculosis (Mtb) in lab tests.
- In mouse models, the delivery of SLMs via inhalation significantly reduced bacterial loads and improved survival rates without causing toxicity, showcasing their potential as a safe and effective treatment option for tuberculosis.
Asthma symptoms, severity, and control with and without a clinical diagnosis of asthma in early adolescence in sub-Saharan Africa: a multi-country, school-based, cross-sectional study.
Lancet Child Adolesc Health
December 2024
Centre for Genomics and Child Health, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. Electronic address:
Article Synopsis
- Rapid urbanization in sub-Saharan Africa is linked to a rise in asthma cases among children and teens, particularly due to challenges in obtaining clinical diagnoses for those exhibiting symptoms.* -
- A two-phase study was conducted across multiple countries involving adolescents aged 12-14, where asthma symptoms were assessed through a questionnaire, and further evaluations were carried out on those with symptoms, including tests for lung function and environmental risk factors.* -
- The study aimed to gather data on the prevalence and severity of asthma in symptomatic adolescents, alongside objective testing methods like spirometry and fractional exhaled nitric oxide (FeNO) to better understand asthma's impact on daily life.*
Evaluation of asthma control after reinforcement of proper inhaler techniques in a tertiary care center in northern India.
Monaldi Arch Chest Dis
October 2024
Department of Pharmacology, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi.
Asthma is an obstructive lung disease with high prevalence. Symptom control in asthma remains poor despite significant advancements in treatment guidelines and inhalational devices. This is often attributed to inadequate patient adherence to the inhaler technique and insufficient education on its long-term use.
View Article and Find Full Text PDFBurden of Asthma Among a Sample of Primary Schoolchildren in Jordan Based on Child and Parental Report.
Public Health Nurs
November 2024
Department of Maternal Child and Family Health, Faculty of Nursing, The Hashemite University, Zarqa, Jordan.
Background: Asthma is a major health issue with an extensive burden to family and health systems. Different measures were used previously to assess disease burden, including prevalence, school performance, parental perceptions, and cost among others.
Aim: The purpose of this study was to assess the burden of asthma among schoolchildren using parental and child reports and metered-dose inhaler (MDI) demonstration.
Examining factors associated with poor metered-dose inhaler technique in a cohort of bronx patients with uncontrolled asthma.
J Asthma
September 2024
Division of Allergy & Immunology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Objective: Most studies investigating at-risk groups for poor inhaler technique (PT) have been in adolescents. However, evidence suggests older age correlates with PT. This study aimed to correlate patient characteristics with PT in an adult asthma cohort in the Bronx.
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