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Neonatal Circulating Amino Acids and Lipid Metabolites Mediate the Association of Maternal Gestational Diabetes Mellitus with Offspring Neurodevelopment at 1 Year.
Nutrients
January 2025
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
: We aimed to identify neonatal circulating metabolic alterations associated with maternal gestational diabetes mellitus (GDM) and to explore whether these altered metabolites could mediate the association of GDM with offspring neurodevelopment. Additionally, we investigated whether neonatal circulating metabolites could improve the prediction of offspring neurodevelopmental disorders over traditional risk factors. : The retrospective cohort study enrolled 1228 mother-child dyads in South China.
View Article and Find Full Text PDFMicrobial diversity and metabolomics analysis of colon contents exposed to cadmium and polystyrene microplastics.
Ecotoxicol Environ Saf
December 2024
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
Cadmium and microplastics, common pollutants, can accumulate in the body, impacting the intestinal barrier and harming livestock breeding. In order to explore the damage mechanism of cadmium and cadmium combined microplastic on the colon of mice, 60 mice were divided into three groups: The control group (0.2 mL of saline), cadmium group (Cd group, 0.
View Article and Find Full Text PDFIgD-CD38br lymphocyte affect myocardial infarction by regulating the glycerol to palmitoylcarnitine (C16) ratio: A Mendelian randomization study.
Medicine (Baltimore)
December 2024
The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin Province, China.
Myocardial infarction, a type of coronary artery disease, results from various factors such as genetic predisposition, lifestyle choices, and immune system regulation. The exact causal links between immune cells, plasma metabolites, and myocardial infarction are currently unclear. Therefore, our study employed the Mendelian randomization approach to explore these potential causal relationships.
View Article and Find Full Text PDFAssociation of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis.
Rev Endocr Metab Disord
November 2024
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Diabetes Research Center of Chinese Academy of Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has short- and long-term adverse effects. Therefore, further exploration of the pathophysiology of GDM and related biomarkers is important. In this study, we performed a systematic review and meta-analysis to investigate the associations between metabolites in blood detected via metabolomics techniques and the risk of GDM and to identify possible biomarkers for predicting the occurrence of GDM.
View Article and Find Full Text PDFPalmitoyl-L-carnitine induces tau phosphorylation and mitochondrial dysfunction in neuronal cells.
PLoS One
November 2024
Division of Brain Disease Research, Department for Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si, Chungcheongbuk-do, Republic of Korea.
Alzheimer's disease (AD) is characterized by cognitive decline and memory loss, involving mechanisms such as tau hyperphosphorylation and mitochondrial dysfunction. Increasing evidence suggests that age-related alterations in metabolite levels are crucial for the pathogenesis of AD. Here, we analyzed serum metabolites from mice of various ages (2, 4, 14, and 21 months old) using mass spectrometry.
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