This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs). After chemotactic and releasing assessments, stromal cell-derived factor 1 and platelet-derived growth factor BB in copolymers were coated on the bone allograft (Allo). Allograft coated with copolymers alone (Allo), as controls, or Allo was implanted into the femur of athymic mice, which received intravenous injections of human MSCs or saline at weeks 1, 2 and 3. At week 8, the total callus volume (both cartilaginous and bony callus) around the allograft was the largest in the Allo + MSC group (p < 0.05). Coating bone allograft with stromal cell-derived factor 1 and platelet-derived growth factor BB and intravenous injections of MSCs improved allograft incorporation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010790 | PMC |
| http://dx.doi.org/10.2217/rme-2018-0063 | DOI Listing |
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