Two new -carboline alkaloids, aspergillspins A-B (-), three new quinolone alkaloids, aspergillspins C-E (-), and two new isocoumarins, aspergillspins F-G (-), together with four known alkaloids were isolated from the marine gorgonian-derived fungus sp. SCSIO 41501. Their structures were identified by spectroscopic analysis, and the absolute configurations of several chiral carbons in and were further established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Their cytotoxic and antibacterial activities were also evaluated.
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