This study examined the relationship between subjective ratings of overall wellness and neuromuscular performance throughout a 6-week intensive offseason strength and conditioning program. Thirty experienced NCAA Division II baseball players completed all phases of the program. A comprehensive wellness rating and 5 countermovement jumps (CMJ5) were measured and averaged for 4 phases of training. Pre- and post-testing measures of strength and speed also were evaluated. Internal consistency of the wellness rating for each phase ranged α = 0.77-0.92, and CMJ5 velocities had decent consistency (ICC = 0.88, TE = 0.19 m·s, CV = 5.90%). The training program evoked significant (p < 0.01) improvements in front squats ( = 0.55), trap bar deadlifts ( = 0.62), chin ups ( = 0.39), 30-yd dash ( = 0.39), with no change in the 300-yd dash (p > 0.05), where is the treatment effect size. Average CMJ5 velocities (m·s) were similar for the preparation phase (1.90 ± 0.25), eccentric phase (1.91 ± 0.28), strength & power phase (1.91 ± 0.24), and recovery phase (1.91 ± 0.30; F = 0.04, p = 0.99, = 0.001). No significant correlations were observed for pre-or post-testing measures of wellness ratings in comparison to any performance measures, including a composite standardized score from each performance test at pre-testing ( = 0.22, p = 0.26). The CMJ5 exhibited too high of a typical error to determine a change in neuromuscular status. Additionally, the wellness rating did not reflect changes in relation to performance.
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http://dx.doi.org/10.70252/ZMAT7063 | DOI Listing |
J Clin Psychiatry
January 2025
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, and Department of Psychiatry, New York University School of Medicine, New York, New York.
There are few established treatments for negative symptoms in schizophrenia, which persist in many patients after positive symptoms are reduced. Oxidative stress, inflammation, and epigenetic modifications involving histone deacetylase (HDAC) have been implicated in the pathophysiology of schizophrenia. Sulforaphane has antioxidant properties and is an HDAC inhibitor.
View Article and Find Full Text PDFJ Clin Psychiatry
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.
To provide proof-of-concept (PoC), dose-range finding, and safety data for BI 1358894, a TRPC4/5 ion channel inhibitor, in patients with borderline personality disorder (BPD). This was a phase 2, multinational, randomized, double-blind, placebo controlled trial. Patients were randomized to oral placebo or BI 1358894 (5 mg, 25 mg, 75 mg, or 125 mg) once daily in a 2.
View Article and Find Full Text PDFHealth Expect
February 2025
University of Toronto Institute for Health Policy, Management and Evaluation, Trillium Health Partners Institute for Better Health, Toronto, Canada.
Introduction: People with lived experience of mental health and/or substance use conditions and their families (PWLE) are increasingly engaged in research, yet rigorous guidelines for engagement are lacking. This study aims to co-design best practice guidelines to support the authentic, meaningful engagement of PWLE in mental health and/or substance use health research.
Methods: A multi-panel modified Delphi study was conducted with 61 expert panelists (35 PWLE and family members, 26 researchers/research support staff from across Canada).
Ann Intensive Care
January 2025
School of Medicine and Psychology, Australian National University, Canberra, Australia.
Background: There is scarce literature evaluating long term psychological or Quality of Life (QoL) outcomes in family members of ICU survivors, who have not experienced invasive ventilation. The objective was to compare long-term psychological symptoms and QoL outcomes in family members of intubated versus non-intubated ICU survivors and to evaluate dyadic relationships between paired family members and survivors.
Methods: Prospective, multicentre cohort study among four medical-surgical ICUs in Australia.
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