Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41440-019-0223-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Melatonin, an Antitumor Necrosis Factor Therapy.
J Pineal Res
January 2025
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Tumor necrosis factor (TNF) is a biomarker of inflammation whose levels are elevated in patients with several diseases associated with dysregulation of the immune response. The main limitations of currently used anti-TNF therapies are the induction of immunodepression, which in many cases leads to serious adverse effects such as infection and cancer, and the inability to cross the blood-brain barrier in neuroinflammatory conditions. Melatonin, in addition to being a chronobiotic compound, is widely known for its antioxidant and immunomodulatory capacity to control inflammatory processes in different pathological contexts.
View Article and Find Full Text PDFMelatonin prevents nicotine-induced hepatotoxicity by modulating apoptosis and histopathological changes in rats.
Pol J Vet Sci
December 2024
Technology and Research Research & Development Center (MARGEM), Hatay Mustafa Kemal University, Hatay, Turkey.
Nicotine, the main toxic component of tobacco, directly or indirectly causes adverse effects on the liver metabolism. Melatonin, secreted by the pineal gland, has anti-apoptotic activity as well as antioxidant activity. The aim of this study was to reveal the antiapoptotic effects of melatonin in rats with experimentally induced chronic liver damage with nicotine.
View Article and Find Full Text PDFThe potential therapeutic role of melatonin in organ fibrosis: a comprehensive review.
Front Med (Lausanne)
December 2024
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Organ fibrosis is a pathological process characterized by the inability of normal tissue cells to regenerate sufficiently to meet the dynamic repair demands of chronic injury, resulting in excessive extracellular matrix deposition and ultimately leading to organ dysfunction. Despite the increasing depth of research in the field of organ fibrosis and a more comprehensive understanding of its pathogenesis, effective treatments for fibrosis-related diseases are still lacking. Melatonin, a neuroendocrine hormone synthesized by the pineal gland, plays a crucial role in regulating biological rhythms, sleep, and antioxidant defenses.
View Article and Find Full Text PDFMelatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation.
J Pineal Res
November 2024
Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
As a chronic gynecological disease, endometriosis is defined as the implantation of endometrial glands as well as stroma outside the uterine cavity. Proliferation is a major pathophysiology in endometriosis. Previous studies demonstrated a hormone named melatonin, which is mainly produced by the pineal gland, exerts a therapeutic impact on endometriosis.
View Article and Find Full Text PDFSleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia.
Neurosci Lett
December 2024
Basic Medical College, Guangxi University of Chinese Medicine, Nanning 530200, China.
This study established an animal model of comorbid depression and insomnia by combining chronic unpredictable mild stress (CUMS) with sleep deprivation (SD). The pathogenesis of comorbid depression and insomnia may be associated with impaired AMPK/FOXO3a signaling, which mediates autophagy inhibition, leading to decreased pineal melatonin secretion. The findings revealed that CUMS + SD rats exhibited more pronounced depression-like behaviors, sleep disorders, increased central oxidative stress, and exacerbated neuroinflammation, accompanied by reduced levels of 5-hydroxytryptophan (5-HT) and melatonin in the pineal gland.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!