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Contemporary Management of the Aortic Valve-Narrative Review of an Evolving Landscape.
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Aortic valve replacement has undergone novel changes in recent decades, providing not only a multitude of procedural options but expanding the treatable patient population. Specifically, a number of minimally invasive and interventional treatment options have allowed for the treatment of high and prohibitive risk surgical patients. Further, technology is allowing for the development of innovative surgical and transcatheter valve models, which will advance the treatment of aortic valve disease in the future.
View Article and Find Full Text PDFThe Thermal Ablation with MRgFUS: From Physics to Oncological Applications.
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Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00100 Rome, Italy.
The growing interest in minimal and non-invasive therapies, especially in the field of cancer treatment, highlights a significant shift toward safer and more effective options. Ablative therapies are well-established tools in cancer treatment, with known effects including locoregional control, while their role as modulators of the systemic immune response against cancer is emerging. The HIFU developed with magnetic resonance imaging (MRI) guidance enables treatment precision, improves real-time procedural control, and ensures accurate outcome assessment.
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Department of Science and Mathematics, Texas A&M University-Central Texas, Killeen, TX 76549, USA.
Gene expansion is a common phenomenon in plant transcription factor families; however, the underlying molecular mechanisms remain elusive. Examples of gene expansion in transcription factors are found in all eukaryotes. One example is plant nuclear factor Y (NF-Y) transcription factors.
View Article and Find Full Text PDFOld Plants for New Food Products? The Diachronic Human Ecology of Wild Herbs in the Western Alps.
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University of Gastronomic Sciences, Piazza Vittorio Emanuele II 9, 12042 Pollenzo, Italy.
This ethnobotanical study examines the traditional knowledge and usage patterns of wild plants in the western Alps, specifically within the Ubaye and Bellino Valleys, through a comparative analysis of data collected from 1983 (published in 1990) to 2024. Our study aims to assess the change in plant usage, species diversity, and the changing roles of plants in local traditions in the western Alpine mountain ecosystems. While the 1983 survey documented medicinal uses centered around pastoralist practices, the 2024 data highlight a notable increase in the use of synanthropic plants, now utilized both medicinally and as food.
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Department of Applied Mathematics, Computer Science and Statistics, Ghent University, 9000 Ghent, Belgium.
Unipept, a pioneering software tool in metaproteomics, has significantly advanced the analysis of complex ecosystems by facilitating both taxonomic and functional insights from environmental samples. From the onset, Unipept's capabilities focused on tryptic peptides, utilizing the predictability and consistency of trypsin digestion to efficiently construct a protein reference database. However, the evolving landscape of proteomics and emerging fields like immunopeptidomics necessitate a more versatile approach that extends beyond the analysis of tryptic peptides.
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