(+) Benzomalvins E () and (-) Benzomalvins E (), a pair of epimeric derivatives, together with three known benzomalvins (), were isolated from solid cultures of a interrhizospheric fungus sp. SYPF 8411. The planar structure of (+) Benzomalvins E () has been previously reported. While, the absolute configuration of compound was established by X-ray crystallographic analysis for the first time. The planar structure of the new compound were elucidated by detailed interpretation of their HR ESI-TOF MS and NMR spectroscopic data. The absolute configuration of compound was established by Rh(OCOCF)-induced CD spectral data and the electronic circular dichroic (ECD) method. Furthermore, the epimerization induced by pH, temperature and HO was revealed. Benzomalvins (), a type of indoximod, enhanced the cytotoxic capability of 5-fluorouracil against A549.
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