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Genetic Determinants of the Re-Emergence of Arboviral Diseases. | LitMetric

Genetic Determinants of the Re-Emergence of Arboviral Diseases.

Viruses

Department of Immunology, School of Medicine, The University of Connecticut Health Center, Farmington, CT 06030, USA.

Published: February 2019

AI Article Synopsis

Article Abstract

Mosquito-borne diseases constitute a large portion of infectious diseases, causing more than 700,000 deaths annually. Mosquito-transmitted viruses, such as yellow fever, dengue, West Nile, chikungunya, and Zika viruses, have re-emerged recently and remain a public health threat worldwide. Global climate change, rapid urbanization, burgeoning international travel, expansion of mosquito populations, vector competence, and host and viral genetics may all together contribute to the re-emergence of arboviruses. In this brief review, we summarize the host and viral genetic determinants that may enhance infectivity in the host, viral fitness in mosquitoes and viral transmission by mosquitoes.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410223PMC
http://dx.doi.org/10.3390/v11020150DOI Listing

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