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Dysregulated miRNA-375, IL-17, TGF-β, and Microminerals Are Associated with Calpain-10 SNP 19 in Diabetic Patients: Correlation with Diabetic Nephropathy Stages.
Int J Mol Sci
December 2023
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Zinc (Zn) and copper (Cu) have been shown to have the potential to improve glucose metabolism through interactions with cytokines and signaling events with multiple genes. miRNA-375 and the Calpin-10 gene are potential genetic biomarkers for the early prediction of diabetic nephropathy (DN). 128 healthy controls and 129 type 2 diabetic (T2DM) participants were matched for age and sex.
View Article and Find Full Text PDFA Target Recycling Amplification Process for the Digital Detection of Exosomal MicroRNAs through Photonic Resonator Absorption Microscopy.
Angew Chem Int Ed Engl
April 2023
Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Article Synopsis
- Exosomal microRNAs (miRNAs) hold great promise as cancer biomarkers for monitoring progression and treatment efficacy.
- The study introduces a target recycling amplification process (TRAP) using photonic resonator absorption microscopy, achieving rapid and sensitive detection of miRNAs.
- TRAP outperforms traditional methods like qRT-PCR, enhancing detection limits significantly and offering a suitable option for low-cost, non-invasive testing of miRNAs in clinical settings.
Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: Regulation of Circulating MicroRNA Expression.
Int J Mol Sci
December 2022
Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi 46000, Pakistan.
MicroRNAs (miRNAs) play a key role in the regulation of genes for normal metabolism in the liver. Dysregulation of miRNAs is involved in the development and progression of non-alcoholic fatty liver disease (NAFLD). We aimed to explore changes in circulating miRNA expression in response to delta-tocotrienol (δT3) and alpha-tocopherol (αTF) supplementation and correlate them with relevant biochemical markers in patients with NAFLD.
View Article and Find Full Text PDFChanges in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial.
Diabetes Care
August 2022
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Objective: To investigate whether changes in circulating levels of pancreatic islet-related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation.
Research Design And Methods: This study included adults with abdominal obesity from an 18-month weight loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months.
Clinical relevance of circulating non-coding RNAs in metabolic diseases: Emphasis on obesity, diabetes, cardiovascular diseases and metabolic syndrome.
Genes Dis
November 2023
Shifa College of Medicine, Shifa Tameer-E-Millat University, Islamabad 45550, Pakistan.
Non-coding RNAs (ncRNAs) participate in the regulation of several cellular processes including transcription, RNA processing and genome rearrangement. The aberrant expression of ncRNAs is associated with several pathological conditions. In this review, we focused on recent information to elucidate the role of various regulatory ncRNAs i.
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