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Clinical and patient-reported outcomes in women offered oncoplastic breast-conserving surgery as an alternative to mastectomy: ANTHEM multicentre prospective cohort study.
Br J Surg
December 2024
Bristol Surgical and Perioperative Care Complex Intervention Collaboration, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, UK.
Background: Oncoplastic breast-conserving surgery may be a better option than mastectomy, but high-quality comparative evidence is lacking. The aim of the ANTHEM study (ISRCTN18238549) was to explore clinical and patient-reported outcomes in a multicentre cohort of women offered oncoplastic breast-conserving surgery as an alternative to mastectomy with or without immediate breast reconstruction.
Methods: Women with invasive/pre-invasive breast cancer who were offered oncoplastic breast-conserving surgery with volume replacement or displacement techniques to avoid mastectomy were recruited prospectively.
A Novel De Novo Missense Variant in Netrin-1 (NTN1) Associated With Chorioretinal Coloboma, Sensorineural Hearing Loss and Polydactyly.
Clin Genet
December 2024
Development, Ageing and Disease, UCL Institute of Ophthalmology, London, UK.
Microphthalmia, anophthalmia and coloboma (MAC) comprise a highly heterogeneous spectrum of congenital ocular malformations with an estimated incidence of 1 in 5000 to 1 in 30 000 live births. Although there is likely to be a genetic component in the majority of cases, many remain without a molecular diagnosis. Netrin-1 was previously identified as a mediator of optic fissure closure from transcriptome analyses of chick and zebrafish and was shown to cause ocular coloboma when knocked out in both mouse and zebrafish.
View Article and Find Full Text PDFEcological and intrinsic drivers of foraging parameters of Eurasian lynx at a continental scale.
J Anim Ecol
November 2024
Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
The estimation of foraging parameters is fundamental for understanding predator ecology. Predation and feeding can vary with multiple factors, such as prey availability, presence of kleptoparasites and human disturbance. However, our knowledge is mostly limited to local scales, which prevents studying effects of environmental factors across larger ecological gradients.
View Article and Find Full Text PDFWhy Is Caries Prevention in Children So Difficult? A Narrative Opinion.
Int J Environ Res Public Health
October 2024
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen, Denmark.
Caries is among the most common non-communicable diseases worldwide, yet it is commonly described as preventable. Caries prevention is, however, difficult and complex, since the disease has strong social, parental, behavioral, political, medical/genetic, and psychological elements, and the payment models are targeted at traditional conservative care. The aim of this paper is to discuss some key issues that make caries prevention in children be perceived as "difficult": i) the communication gap between researchers and clinicians, creating unrealistic expectations of intervention efficacy; ii) the skewed distribution of caries and the problem of reaching children with the highest need; iii) limited access to care, which is a threat to oral health, in particular in low-socioeconomic-status, underserviced, and remote communities; and iv) the need to adopt behavior change models to affect the modifiable risk factors that are shared with other non-communicable diseases.
View Article and Find Full Text PDFAssociation between kidney function, frailty and receipt of invasive management after acute coronary syndrome.
Open Heart
October 2024
Population Health Sciences, University of Bristol, Bristol, UK.
Article Synopsis
- A study analyzed data from over 10,000 patients with acute coronary syndrome (ACS) from 2010 to 2017 to explore the impact of reduced kidney function (eGFR) on treatment and mortality rates.
- It found that lower eGFR levels were strongly linked to a decrease in invasive treatments like coronary angiography; patients with eGFR <30 were significantly less likely to receive these procedures compared to those with higher eGFR.
- Additionally, there was a clear connection between lower eGFR and higher 30-day mortality rates, indicating that kidney function plays a critical role in treatment outcomes for ACS patients.
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