Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372657 | PMC |
| http://dx.doi.org/10.1038/s41598-019-38752-y | DOI Listing |
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