AI Article Synopsis
- Precision medicine has led to advancements in molecular pathology, particularly in using exhaled breath as a non-invasive diagnostic tool.
- The study focuses on a new method for analyzing breath samples, utilizing advanced techniques like thermal desorption combined with comprehensive gas chromatography.
- Results showcase a well-optimized protocol for collecting and analyzing volatile organic compounds (VOCs), crucial for integrating breath analysis into large clinical studies.
Article Abstract
Precision medicine has spurred new innovations in molecular pathology leading to recent advances in the analysis of exhaled breath as a non-invasive diagnostic tool. Volatile organic compounds (VOCs) detected in exhaled breath have the potential to reveal a wealth of chemical and metabolomic information. This study describes the development of a method for the analysis of breath, based on automated thermal desorption (TD) combined with flow modulated comprehensive two-dimensional gas chromatography (GC×GC) with dual flame ionisation and quadrupole mass spectrometric detection (FID and qMS). The constrained optimisation and analytical protocol was designed to meet the practical demands of a large-scale multi-site clinical study, while maintaining analytical rigour to produce high fidelity data. The results demonstrate a comprehensive method optimisation for the collection and analysis of breath VOCs by GC×GC, integral to the standardisation and integration of breath analysis within large clinical studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491496 | PMC |
| http://dx.doi.org/10.1016/j.chroma.2019.02.001 | DOI Listing |
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