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The effect of micro-vessel viscosity on the resonance response of a two-microbubble system.
Ultrasonics
December 2024
Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. Electronic address:
Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubble-bubble interaction and the effects of a neighboring viscoelastic vessel wall, remain poorly understood. In this work, we developed a finite element model to study the physics of the complex system of two different-sized bubbles (2 and 3 µm in diameter) confined within a viscoelastic vessel from a resonance response perspective (3-12 MHz).
View Article and Find Full Text PDFExperimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles.
Ultrason Sonochem
December 2024
Toronto Metropolitan University, 350 Victoria Street, Toronto, Ontario, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between St. Michael's Hospital and Toronto Metropolitan University, 209 Victoria St, Toronto, Ontario, Canada.
This study presents an experimental investigation of the influence of MB concentration on the resonance frequency of lipid-coated microbubbles (MBs). Expanding on theoretical models and numerical simulations from previous research, this work experimentally investigates the effect of MB size on the rate of resonance frequency increase with concentration, a phenomenon observed across MBs with two different lipid compositions: propylene glycol (PG) and propylene glycol and glycerol (PGG). Employing a custom-designed ultrasound attenuation measurement setup, we measured the frequency-dependent attenuation of MBs, isolating MBs based on size to generate distinct monodisperse sub-populations for analysis.
View Article and Find Full Text PDFLetter to the editor: Safety of contrast-enhanced ultrasound using microbubbles in human pregnancy: A scoping review.
Ultraschall Med
December 2024
Obstetric and fetal medicine Unit, Centre Hospitalier Régional Universitaire de Nancy Maternité Régionale Adolphe Pinard, Nancy, France.
Microbubble enhanced ultrasound with low mechanical index promotes therapeutic angiogenesis in hind limb ischemia mouse model.
Med Phys
December 2024
Department of Ultrasound, Xinqiao Hospital, Army Medical University, Chongqing, China.
Background: Microbubble enhanced ultrasound (MEUS) can augment tissue perfusion by angiogenesis yet the best treatment ultrasound power in the initial ischemia period is uncertain.
Purpose: Considering the mechanical index (MI) is the most commonly used parameter for regulating diagnostic ultrasound power, here, we explored the effects of MEUS mediated by different MI on perfusion and sought to characterize the angiogenesis in the early stage of ischemia.
Methods: Experiments were conducted on hind limb ischemia mouse model (HLI) and MEUS was administrated in the first week every other day following induction of HLI for four times.
Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer?
Front Oncol
November 2024
Department of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Objectives: We evaluated the ability and accuracy of preoperative identification and localization of sentinel lymph nodes (SLNs) using intradermal injection of ultrasound contrast agent.
Materials And Methods: Prospectively recruited 191 early breast cancer patients with clinically negative axillary lymph nodes (ALNs). All participants received intradermal injection of microbubble contrast agent.
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