AI Article Synopsis
- Gli proteins are key transcription factors in the Hedgehog signaling pathway, crucial for organ and tissue development, with implications in birth defects and cancer.
- The review focuses on how Gli proteins are regulated at the molecular level, particularly through posttranslational modifications and their transport within cells, as well as their interactions with co-activators and co-repressors that influence gene expression.
- Lastly, the overview highlights the role of Gli proteins in developmental processes, tissue regeneration, and their involvement in cancer progression, integrating both direct Hedgehog pathway actions and interactions with other signaling pathways.
Article Abstract
Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttranslational modifications and intracellular transport. We also discuss how Gli proteins interact with co-activators and co-repressors to fine-tune the expression of Hedgehog target genes. Finally, we provide an overview of the regulation of developmental processes and tissue regeneration by Gli proteins and discuss how these proteins are involved in cancer progression, both through canonical regulation via the Hedgehog pathway and through cross-talk with other signaling pathways.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406693 | PMC |
| http://dx.doi.org/10.3390/cells8020147 | DOI Listing |
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