AI Article Synopsis
- The study examines how insulin and leptin influence fat tissue expansion through specific genes and enzymes connected to fat storage and breakdown.
- Data was collected from 38 individuals who underwent gallbladder surgery, analyzing gene expression in liver and adipose tissues alongside measures of body fat and composition.
- Results showed higher expression of certain genes linked to fat storage in obese individuals compared to lean and overweight counterparts, indicating a relationship between these genes, fat distribution, and leptin levels.
Article Abstract
The expansion of adipose tissue is regulated by insulin and leptin through sterol regulatory element-binding protein-1c (SREBP-1c), up-regulating lipogenesis in tissues by Stearoylcoenzyme A desaturase 1 (SCD1) enzyme, while adipose triglyceride lipase (ATGL) enzyme is key in lipolysis. The research objective was to evaluate the expression of Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1), SCD1, Patatin Like Phospholipase Domain Containing 2 (PNPLA2), and leptin (LEP) genes in hepatic-adipose tissue, and related them with the increment and distribution of fat depots of individuals without insulin resistance. Thirty-eight subjects undergoing elective cholecystectomy with liver and adipose tissue biopsies (subcutaneous-omental) are included. Tissue gene expression was assessed by qPCR and biochemical parameters determined. Individuals are classified according to the body mass index, classified as lean (control group, n=12), overweight (n=11) and obesity (n=15). Abdominal adiposity was determined by anthropometric and histopathological study of the liver. Increased expression in omental adipose tissue (p=0.005) and in liver (p=0.01) were found in the obesity group. decreased expression in subcutaneous adipose tissue was significant in individuals with abdominal adiposity (p=0.017). Anthropometric parameters positively correlated with liver and the expression of liver with serum leptin. increased levels may represent lipid storage activity in omental adipose tissue. Liver increased expression could function as a primary compensatory event of visceral fat deposits associated to the leptin hormone related to the increase of adipose tissue.
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| http://dx.doi.org/10.1055/a-0829-6324 | DOI Listing |
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