Purpose: Interaction is the process of behavior adaption between two or more participants primarily based on what they visually perceive. It is an important aspect of traffic participation and supports a safe and efficient flow of traffic. However, prior driving simulator studies investigating the effects of vision impairment have typically used pre-programmed pedestrians that did not interact with the human driver. In the current study we used a linked pedestrian and driving simulator setting to increase the ecological validity of the experimental paradigm. We evaluated the effects of mild vision loss on interactions between drivers and human-controlled, interactive pedestrians compared to preprogrammed, non-interactive pedestrians.
Method: Young subjects (mean age 31 years) wore safety goggles with diffusing filters that reduced visual acuity to 20/50 Snellen and contrast sensitivity to 1.49 log units. Two types of crossings (zebra vs. free lane) and two types of pedestrians (non-interactive vs. interactive) were presented to the driver using a multiple simulator setting. Gaze, safety and time series measures were analyzed to quantify the behavior of the participants during the different crossing situations.
Results: Simulated vision impairment significantly increased the time taken to first fixate on the pedestrian, but only had mild adverse effects on safety measures and subsequent interactions. By comparison, pedestrian type and crossing type were found to significantly affect interaction measures. In crossings with the interactive pedestrians the behavior adaption between the driver and the pedestrian took longer and was less correlated in contrast to the situations with the non-interactive pedestrian.
Conclusion: Mild vision impairment (slightly worse than the common 20/40 requirement for driving) had little effect on interactions with pedestrians once they were detected and only had mild adverse consequences on driving safety. Time series measures were sensitive to differences in behavior adaption between road users depending on the level of interaction and type of crossing situation.
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http://dx.doi.org/10.1016/j.aap.2019.01.026 | DOI Listing |
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 N Michigan Ave, Suite 440, Chicago, IL, 60611, USA.
Purpose: To report a case of transient diplopia and upgaze paresis in the setting of acute dorsal midbrain infarcts from a cervical vertebral artery dissection in an otherwise healthy man.
Observations: A 33-year old man presented to the ophthalmology urgent clinic with a 1 h history of blurred and double vision, asthenopia, and a mild focal left posterior headache. Ocular motility examination revealed a profound upgaze palsy and convergence-retraction horizontal jerk nystagmus in attempted upgaze that gradually improved over the course of 1 h.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Purpose: To describe a rare case of presumed bilateral acute idiopathic maculopathy (AIM) in a pediatric patient.
Observation: An 11-year-old male was evaluated for a "fuzzy Dorito-shaped" spot in the central vision of his right eye (OD) that started 3 days before presenting to our clinic. On examination, best-corrected visual acuity (BCVA) was counting fingers at 5 feet OD, and 20/25 in the left eye (OS).
Poult Sci
December 2024
Animal Breeding and Genomics, Wageningen University & Research, 6700 AH Wageningen, the Netherlands.
Impaired walking ability and leg health are commonly seen in broilers and can negatively impact their welfare. Commonly, walking ability and leg health are assessed manually, but this is time consuming and can be subjective. Automated approaches for scoring walking ability and leg health at the individual level could therefore have great added value.
View Article and Find Full Text PDFCardiovasc Diagn Ther
December 2024
East Slovak Institute of Cardiovascular Diseases and School of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia.
Background: Echocardiography is widely used to assess aortic stenosis (AS) but can yield inconsistent results, leading to uncertainty about AS severity and the need for further diagnostics. This retrospective study aimed to evaluate a novel echocardiography-based marker, the signal intensity coefficient (SIC), for its potential in accurately identifying and quantifying calcium in AS, enhancing noninvasive diagnostic methods.
Methods: Between May 2022 and October 2023, 112 cases of AS that were previously considered severe by echocardiography were retrospectively evaluated, as well as a group of 50 cases of mild or moderate AS, both at the Eastern Slovak Institute of Cardiovascular Diseases in Kosice, Slovakia.
JAMA Ophthalmol
January 2025
Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China.
Importance: Bietti crystalline dystrophy (BCD) is a severe genetic retinopathy caused by variants in the CYP4V2 gene. Currently, there is no approved treatment for BCD.
Objective: To evaluate safety and vision outcomes following gene therapy with adeno-associated virus (AAV) encoding CYP4V2 (rAAV-hCYP4V2, NGGT001 [Next Generation Gene Therapeutics]).
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