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Looking at the albumin-drug binding via partitioning in aqueous two-phase system.
Biochem Biophys Res Commun
January 2025
Cleveland Diagnostics, 3615 Superior Ave., Cleveland, OH, 44114, USA. Electronic address:
The partition coefficient of human serum albumin (HSA) was analyzed in the PEG600-Dex70, 0.15 M NaCl/KCl in 0.01 M Na/K phosphate buffer, pH 7.
View Article and Find Full Text PDFRole of aminophylline in prevention of acute kidney injury in term neonates with severe perinatal asphyxia: a randomized open-label controlled trial.
J Trop Pediatr
October 2024
Department of Health and Family Welfare, Swasthya Bhawan, Kolkata, West Bengal 700091, India.
Article Synopsis
- Acute kidney injury (AKI) is a common complication in neonates who experience severe perinatal asphyxia, and the role of aminophylline in preventing it is debated.
- A study involving 81 severely asphyxiated term neonates evaluated the effectiveness of aminophylline as an adjunct to standard care, showing a lower but not statistically significant incidence of AKI in the aminophylline group compared to the control group.
- While aminophylline treatment seemed to temporarily improve urine output, it did not significantly change renal function or lower AKI rates overall.
Exhaustive Search of Dietary Intake Biomarkers as Objective Tools for Personalized Nutrimetabolomics and Precision Nutrition Implementation.
Nutr Rev
September 2024
Nutrition Precision and Cardiometabolic Health Program of IMDEA-Food Institute (Madrid Institute for Advances Studies), 28040, Madrid, Spain.
Objective: To conduct an exhaustive scoping search of existing literature, incorporating diverse bibliographic sources to elucidate the relationships between metabolite biomarkers in human fluids and dietary intake.
Background: The search for biomarkers linked to specific dietary food intake holds immense significance for precision health and nutrition research. Using objective methods to track food consumption through metabolites offers a more accurate way to provide dietary advice and prescriptions on healthy dietary patterns by healthcare professionals.
Background: Previous studies reported that variations in dietary intake patterns substantially impact human health, specifically tumorigenesis. However, confounding factors in previous cohort studies have obscured the relationship between dietary differences and the risk of oral cancer (OC).
Materials And Methods: We developed an outcome dataset from genome-wide association studies (GWAS) data on three OCs within the GAME-ON project, using GWAS-META merging.
Evaluation and clinical application of a bracketing calibration-based isotope dilution liquid chromatography-tandem mass spectrometry candidate reference measurement procedure for serum theophylline.
Anal Bioanal Chem
September 2024
Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.
A candidate reference measurement procedure (RMP) for serum theophylline via isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. With a single-step precipitation pretreatment and a 6-min gradient elution, the method achieved baseline separation of theophylline and its analogs on a C18-packed column. A bracketing calibration method was used to ensure repeatable signal intensity and high measurement precision.
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