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Strychni Semen and two alkaloidal components cause apoptosis in HK-2 cells through TRADD-MAPK/NF-κB Pathway.
Toxicon
January 2025
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:
Strychni Semen is the dried ripe seeds of the plant Strychnos nux-vomica L, and has great medicinal value and developmental potential.However, Strychni Semen is severely toxic, with adverse effects on the central nervous system, urinary system, and other organ systems, and severe cases can be life-threatening. The present study was to reveal the mechanism of nephrotoxicity induced by Strychni Semen and its alkaloid components using experiments.
View Article and Find Full Text PDFEffect of respiratory rehabilitation on quality of life in individuals with post-COVID-19 symptoms: A randomised controlled trial.
Ann Phys Rehabil Med
January 2025
Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM); IdISSC, Madrid, Spain.
Background: Inspiratory and expiratory muscle training (RMT) has been shown to have beneficial effects in individuals with long-term post-COVID-19 symptoms.
Objective: To assess the effects of adding RMT to an aerobic exercise (AE) training program for health-related quality of life (HRQoL) and exercise tolerance in individuals with long-term post-COVID-19 symptoms, and to evaluate the effects on physical and lung function, and psychological status.
Methods: 64 individuals with long-term post-COVID-19 symptoms of fatigue and dyspnoea were randomly assigned to AE+RMT or AE+RMT groups for an 8-wk intervention (AE: 50min/day, 2 times/wk; RMT: 40min/day, 3 times/wk).
Introduction: Pediatric anxiety is rapidly increasing, and in 2022, the US Preventive Services Task Force recommended universal anxiety screening using a validated tool for children 8-18 years.
Method: This evidence-based practice quality improvement initiative integrated an educational process, a validated anxiety screening tool, and a Caregiver Satisfaction Survey into all primary care wellness visits for patients aged 8-18 years.
Results: Significant increases in screening and referrals for mental healthcare were observed postinitiative implementation, especially in ages 8-11 years.
Carbohydrate Mouth Rinsing Improves Softball Launch Angle Consistency: A Double-Blind Crossover Study.
Nutrients
January 2025
Graduate Program in Department of Exercise Health Science, National Taiwan University of Sport, Taichung 404, Taiwan.
(1) Background: Carbohydrate mouth rinsing (CMR) stimulates the central nervous system and improves motor control. However, no studies have examined the effects of CMR on softball batting performance. The purpose of this study was to investigate the effect of CMR on softball batting performance.
View Article and Find Full Text PDFImpact of the COVID-19 pandemic on the mental health of Nursing students: A systematic review and meta-analysis.
Medicine (Baltimore)
January 2025
Centro Universitario de Enfermería Cruz Roja, University of Seville, Seville, Spain.
Background: There is an increased prevalence of mental health problems in various population groups as a result of the COVID-19 pandemic and its consequences, especially regarding anxiety, stress, depression, fear, and sleep disturbances, require to be investigated longitudinally.
Objective: This study aimed to determine the impact that the COVID-19 pandemic had on the mental health of Nursing students, as well as to examine other associated factors such as anxiety, fear, sleep disturbances, and coping strategies.
Method: This systematic review and meta-analysis were designed following the PRISMA guidelines and were registered in PROSPERO with code CRD42024541904.
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