A lysosome-targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid. More importantly, the real-time tracking of the dynamic movement of lysosomes, as vesicle structures, has been achieved using Lyso-MC.
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A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid.
Chem Commun (Camb)
February 2019
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China.
A lysosome-targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid. More importantly, the real-time tracking of the dynamic movement of lysosomes, as vesicle structures, has been achieved using Lyso-MC.
View Article and Find Full Text PDFBright and photostable fluorescent probe with aggregation-induced emission characteristics for specific lysosome imaging and tracking.
Talanta
October 2016
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China. Electronic address:
We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton. Due to both the AIE and antenna effects, TPE-MPL possesses superior photostability, appreciable tolerance to microenvironment change and high lysosome targeting ability. Our findings confirm that TPE-MPL is a well-suited imaging agent for targeting lysosome and tracking dynamic movement of lysosome.
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