AI Article Synopsis
- Researchers developed a new compound, a tris-CDTA complex, that can improve imaging techniques by combining PET and MR through the use of manganese isotopes, 55Mn(ii) and 52gMn(ii).
- This complex has 144% better longitudinal relaxivity (r1) compared to a single manganese-CDTA unit, which enhances the clarity of MR images.
- Additionally, the tris-CDTA complex includes a linker that allows it to attach to biomolecules, enabling targeted imaging of specific areas in biological systems.
Article Abstract
trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(ii) and β+-emitting 52gMn(ii) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.
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| http://dx.doi.org/10.1039/c8dt04996c | DOI Listing |
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