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Diagnostic Difficulties of Erosive Lichen Planus in a Pediatric Patient.
Diagnostics (Basel)
December 2024
Department of Dermatology, Medical University of Warsaw, 02-006 Warsaw, Poland.
Lichen planus (LP) is a chronic inflammatory disease that can present with significant morbidity, particularly in children. Erosive lichen planus (ELP), its rare destructive subtype, can be particularly difficult to diagnose and manage. We present a rare pediatric case of ELP with multisite involvement and discuss the differential diagnosis.
View Article and Find Full Text PDFData cleaning and harmonization of clinical trial data: Medication-assisted treatment for opioid use disorder.
PLoS One
November 2024
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
Several large-scale, pragmatic clinical trials on opioid use disorder (OUD) have been completed in the National Drug Abuse Treatment Clinical Trials Network (CTN). However, the resulting data have not been harmonized between the studies to compare the patient characteristics. This paper provides lessons learned from a large-scale harmonization process that are critical for all biomedical researchers collecting new data and those tasked with combining datasets.
View Article and Find Full Text PDFRecommendations for the Design and Implementation of Alcohol Pharmacotherapy Trials: Perspectives of Women With HIV Participating in the WHAT-IF Study.
J Addict Med
November 2024
From the Department of Epidemiology, College of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, FL (RJF-H, SR, AG, NS, CEP, RLC, SC); Department of Biobehavioral Nursing Science, College of Nursing, University of Florida (IP), Gainesville, FL.
Objectives: Naltrexone for alcohol reduction has been poorly studied in women with HIV (WWH), for whom heavy alcohol use is associated with negative HIV outcomes. This study offers recommendations for researchers conducting alcohol pharmacotherapy trials among PWH as suggested by WWH who participated in an alcohol pharmacotherapy trial in Florida.
Methods: The WHAT-IF? Study enrolled WWH with a history of heavy alcohol use in Miami, Florida, into a clinical trial where participants were randomized to receive naltrexone or placebo to assess effectiveness among WWH.
Kratom Consumption - The Tales of Three Patients.
J Psychoactive Drugs
November 2024
Psychiatry Department, Dartmouth's Geisel School of Medicine, Hanover, NH, USA.
The rising prevalence of kratom use in the United States has led to increased encounters with individuals who consume kratom and those who develop Kratom Use Disorder (KUD) among healthcare professionals. This case series highlights the need for diverse treatment approaches tailored to the individual motivations for kratom consumption. Three cases are presented: one involving the progression from kratom use for energy to opioid-driven use with subsequent challenges in detoxification and transition to naltrexone necessitating buprenorphine low-dose induction for maintenance; another detailing successful inpatient detoxification using methadone and symptom-driven clonidine, followed by successful maintenance treatment with naltrexone; and a final case involving kratom consumption for pain and anxiety self-management by an individual without a history of addictive disorders, without meeting KUD criteria.
View Article and Find Full Text PDFCorrelates of post-hospitalization naltrexone adherence for alcohol use disorder.
Drug Alcohol Depend
December 2024
Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA; Section of General Internal Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA; Grayken Center for Addiction, Boston Medical Center, Boston, MA, USA.
Introduction: Hospitalizations present an opportunity to initiate naltrexone for patients with alcohol use disorder (AUD). Understanding factors associated with post-hospitalization adherence could inform practice.
Methods: This study is a secondary analysis of a clinical trial in which patients with AUD were randomized to oral (PO) versus long-acting injectable (LAI) naltrexone at hospital discharge.
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