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TRAIL agonists rescue mice from radiation-induced lung, skin or esophageal injury.
J Clin Invest
January 2025
Laboratory of Translational Oncology and Translational Cancer Therapeutics, Warren Alpert Medical School of Brown University, Providence, United States of America.
Radiotherapy can be limited by pneumonitis which is impacted by innate immunity, including pathways regulated by TRAIL death receptor DR5. We investigated whether DR5 agonists could rescue mice from toxic effects of radiation and found two different agonists, parenteral PEGylated trimeric-TRAIL (TLY012) and oral TRAIL-Inducing Compound (TIC10/ONC201) could reduce pneumonitis, alveolar-wall thickness, and oxygen desaturation. Lung protection extended to late effects of radiation including less fibrosis at 22-weeks in TLY012-rescued survivors versus un-rescued surviving irradiated-mice.
View Article and Find Full Text PDFMachine learning prediction model for oral mucositis risk in head and neck radiotherapy: a preliminary study.
Support Care Cancer
January 2025
Oral Diagnosis Department, Faculdade de Odontolodia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Purpose: Oral mucositis (OM) reflects a complex interplay of several risk factors. Machine learning (ML) is a promising frontier in science, capable of processing dense information. This study aims to assess the performance of ML in predicting OM risk in patients undergoing head and neck radiotherapy.
View Article and Find Full Text PDF[Ophthalmic oncology in a warmer world: climate-related increase in the prevalence of eyelid cancer].
Ophthalmologie
January 2025
Klinik für Augenheilkunde, Klinikum Chemnitz, Flemmingstr. 2, 09116, Chemnitz, Deutschland.
Background: Damage induced by ultraviolet (UV) radiation plays a decisive role in the carcinogenesis of malignant tumors of the eyelids.
Methods: A selective literature search was performed in PubMed and Google Scholar.
Results: Large epidemiological studies show an increase in the prevalence of eyelid tumors in recent decades.
Skeletal surveys for suspected infant abuse: patient-specific radiation dose estimation using a hybrid computational phantom.
Pediatr Radiol
January 2025
Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Background: Radiographic skeletal survey plays an important role in the diagnosis of infant abuse. Some practitioners have expressed concerns about the radiation exposure from this examination.
Objective: To utilize state-of-the-art hybrid computational phantoms to more accurately estimate radiation doses of skeletal surveys performed for suspected infant abuse.
Influences of light-dark cycle and water temperature on in vitro egg laying, hatching, and survival rate of the Thaparocleidus vistulensis (Dactylogyridea: Ancylodiscoididae).
Parasitol Res
January 2025
HUN-REN Veterinary Medical Research Institute, 21, Hungária Krt, 1143, Budapest, Hungary.
The European catfish (Silurus glanis) is an important species with high economic value, and its growing demand has led to intensive farming practices for it. However, this species is increasingly challenged by parasitic infections, particularly from a specific gill monopisthocotylan parasite called Thaparocleidus vistulensis. To establish effective management strategies, it is crucial to comprehend the fundamental environmental variables that could influence the reproductive and survival behavior of T.
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